电压门控钠通道的β亚基调控机制  

Regulation mechanism of voltage-gated sodium channels by β-subunits

作　　者：吴艳艳[1] 刘霞[1] 白占涛[1] 

机构地区：[1]延安大学生命科学学院,多肽资源药物研究中心,陕西省区域生物资源保育利用工程技术研究中心,延安716000

出　　处：《生命的化学》2016年第5期655-660,共6页Chemistry of Life

基　　金：国家自然科学基金项目(81470051;81171038);陕西省科技厅项目(2010JM4041;2011K17-01-04;2012K01-12);陕西省教育厅项目(12JS121;15JF034);延安大学陕西省高水平大学建设项目(2012SXTS06);延安市资源药物研究与利用科技创新团队和榆林市科技计划项目(2015CXY-21)

摘　　要：电压门控钠通道是细胞电兴奋的重要分子基础,由一个α孔道亚基和单个或多个β辅助亚基构成。β亚基以直接与钠通道α亚基结合或以细胞粘附分子方式,组合或单独调节α亚基的表达定位及门控特性。因此,β亚基与α亚基不同亚型的细胞特异性表达组合,是神经元内在特性的内源性调控机制之一。本文基于钠通道β亚基不同亚型差异表达与功能的多样性调控,解析疼痛、癫痫等通道病发生发展的β亚基相关机制,以期为靶向电压门控钠通道的临床诊疗和新药发现提供新策略。Voltage-gated sodium channels, which are the molecular foundation of cellular electronic excitation, are composed of one α pore-forming subunit and one or more subunits. β subunits could regulate the expression and gating traits of α subunit by binding directedly with single one lonely or together with the other, and/or by cellular adhesion molecular patterns indirectedly. Thus, the distinct functional combination of sodium channel β and α subunits should underlie the specific intrinsic characters of neurons. To elucidate the βsubunits-related endogenous mechanisms of channelopathies such as pain and epilepsy, the paper reviews the diverse structure, localization and functional regulation of β subunits, and hopes to provide the novel strategy for clinical therapy and drug discovery targeting to voltage-gated sodium channels.

关 键 词：电压门控钠通道 Β亚基 细胞粘附分子 疼痛 癫痫 调控机制 

分 类 号：R363[医药卫生—病理学]