二氟甲基鸟氨酸在实体瘤防治的应用现状  

Application of difuloromethylornithine in solid tumors

作　　者：叶丛[1] 耿哲[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院风湿免疫科,湖北武汉430030 [2]湖北省妇女儿童医院儿童血液科,湖北武汉430070

出　　处：《中华肿瘤防治杂志》2016年第16期1124-1128,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：国家自然科学基金青年科学基金(81501415)

摘　　要：目的近年来,二氟甲基鸟氨酸(difuloromethylornithine,DFMO)这一"老药"在肿瘤,尤其是实体瘤防治领域重新受到重视,本研究拟对目前国内外有关其防治肿瘤的研究进展作一综述。方法应用PubMed和CNKI期刊全文数据库检索系统,以"二氟甲基鸟氨酸、肿瘤、化学预防和化学治疗"为关键词,检索2000-01-2016-01有关文献。共检索英文文献175篇,中文文献16篇。纳入标准:(1)DFMO预防和治疗肿瘤的基础研究;(2)DFMO预防和治疗肿瘤的临床药物试验。排除标准:(1)DFMO制备技术的研究;(2)其他鸟氨酸脱羧酶(ornithine decarboxylase,ODC)抑制剂的研究。最终分析文献33篇。结果 DFMO防治肿瘤的机制主要包括抑制ODC从而降低体内多胺水平和影响肿瘤免疫微环境等。目前的动物及临床试验发现其单药或与其他药物联用,对多种实体恶性肿瘤,尤其是结肠癌等上皮来源的肿瘤有较好的防治效果。并且DFMO还具有其毒副作用低、价格相对低廉、从科研到临床转化迅速等多方面优点。结论作为一种有效、安全的化疗预防或治疗药物,DFMO单药或与其他治疗方式的联合应用体现出令人期待的前景。但为了达到"老药新用"的目的,大量研究工作仍有待进一步展开。OBJECTIVE The antitumor function of Difuloromethylornithine （DFMO） ,especially in solid tumors,has been paid renewed attention in recent years. The purpose of this study was to summarize the research progress of chemoprevention and chemotherapy by DFMO. METHODS The PubMed and CNKI database from Jan 2000 to Jan 2016 were filtered using ＂Difuloromethylornithine,neoplasms,chemoprevention,chemotherapy＂ as keywords. A total of 175 English papers and 16 Chinese papers were obtained. Inclusion criteria： basic research of DFMO as a chemopreventive and/or chemotherapeutic drug; clinical trials of DFMO as a chemopreventive and/or chemotherapeutic agent. Exclusion criteria： progress on preparation of DFMO; research on other ornithine decarboxylase （ODC） inhibitors. Eventually 33 papers were analyzed. RESULTS The chemopreventive or chemotherapeutic mechanisms of DFMO include decreasing polyamine by inhibiting ODC activity and reversing immunosuppression in the tumor microenvironment. And other mechanisms un- derlying the DFMO effect are still being explored. The results of the recent studies indicated that DFMO, as a single agent or in combination with other therapy,has remarkable preventive or therapeutic effect on multiple solid neoplasms, especial- ly cancers of epithelial origin, such as colon cancer. Compared with other chemotherapeutic drugs, DFMO is endowed with a high degree of safety and tolerability and is relatively inexpensive. Moreover,since DFMO is a FDA approved agent,the rapid translation of preclinical findings into the clinic can therefore be expected. CONCLUSIONS It is promising to use DFMO alone and in combination in effective prevention or treatment of neoplasms, although further studies are still needed for repurposing of this ＂old agent＂ for new cancer indications.

关 键 词：二氟甲基鸟氨酸 鸟氨酸脱羧酶 肿瘤 化学预防 化学疗法 综述文献 

分 类 号：R730.5[医药卫生—肿瘤]