单核苷酸多态性rs1885068与不同卒中亚型长期预后的关系  

Association of Single Nucleotide Polymorphism rs1885068 with Stroke Subtypes Prognosis

作　　者：吴涛[1] 邱石[1] 宋莉[2] 宋燕[2] 张银辉[2] 陈敬洲[2] 杜继臣[1] 

机构地区：[1]北京大学航天临床医学院,北京市100049 [2]北京协和医学院中国医学科学院国家心血管病中心阜外医院心血管病国家实验室,北京市100037

出　　处：《中国分子心脏病学杂志》2016年第4期1782-1786,共5页Molecular Cardiology of China

基　　金：国家自然科学基金(课题号91539113)

摘　　要：目的探究单核苷酸多态性rs1885068不同基因型与不同卒中亚型长期预后的相关性。方法采用前瞻性队列研究设计。通过对不同卒中亚型患者约4.5年的随访,记录患者卒中复发和全因死亡情况,分析单核苷酸多态性rs1885068不同基因型与卒中患者长期预后的相关性。使用聚合酶链式反应-连接酶检测反应(PCR-LDR)检测卒中患者单核苷酸多态性rs1885068的基因型。结果对不同卒中亚型患者随访后发现,单核苷酸多态性rs1885068与腔隙性脑梗死患者的长期预后呈显著相关(log-rank P=0.034)。Cox比例风险模型校正年龄、性别、高血压、糖尿病、吸烟史、饮酒史后,结果显示单核苷酸多态性rs1885068 T等位基因增加脑卒中复发和全因死亡1.65倍风险(HR=1.65;95%CI=1.04-2.61;P=0.032)。而单核苷酸多态性rs1885068不同基因型与大动脉粥样硬化性卒中和脑出血的长期预后无相关性。结论单核苷酸多态性rs1885068与腔隙性脑梗死的长期预后相关,是其预后的强预测因子。Objective To investigate the association of rs1885068 with the prognosis of different stroke subtypes. Methods Cohort study design was conducted to investigate the association of rs 1885068 with stroke subtypes prognosis. After a median follow-up period of 4.5 years, the events of stroke recurrence and all cause death were recorded to investigate the association of rs1885068 with the prognosis of stroke subtypes. The genotypes of rs 1885068 were analyzed by polymerase chain reaction ligation-detection reaction. Results a significant difference was found between rs 1885068 and the long-term outcomes of lacunar infarction （log-rank P=0.034）. After adjusting for age, sex, hypertension, diabetes, alcohol, and smoking, Cox proportional hazard analysis indicated that the rs1885068 T allele caused a 1.65-fold increased risk of stroke recurrence and all-cause death （hazards ratio=1.65; 95% CI=1.04-2.61; P=0.032）. However, there was no significant association between rs 1885068 and the prognosis of large artery atherosclerosis and intracranial hemorrhage. Conclusions SNP rs 1885068 may be associated with the prognosis of lacunar infarction, and appears to be a effective predictor of lacunar infarction prognosis.

关 键 词：卒中 单核苷酸多态性 长期预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]