职业应激与5-羟色胺2A受体基因多态性对热电厂工人抑郁症状的影响  

Influence of occupational stress and 5-hydroxytryptamine 2A receptor gene polymorphisms on depression in workers in a thermal power plant

作　　者：吴辉 王芳芳[2] 周文慧 谷桂珍 余善法 

机构地区：[1]河南省职业病防治研究院,郑州450052 [2] 濮阳市疾病预防控制中心

出　　处：《中华劳动卫生职业病杂志》2016年第10期721-725,共5页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：河南省医学科技攻关计划重大项目（201001009）;河南省卫生科技创新型人才工程科技领军人才基金（3022）

摘　　要：目的 探讨职业应激和5-羟色胺（5-HT）2A受体基因多态性与抑郁症状的关系.方法 2010年11月,以整群抽样的方法抽取某热电厂589名工人为研究对象.使用问卷调查其人口统计学特征和职业应激相关因素.采用聚合酶链式反应-限制性片段长度多态性技术（PCR-RFLP）检测589名工人的5-HT2A受体T102C和A-1438G位点的基因型.结果 高水平每日紧张感（0R=3.013,95％CI：1.642～5.530）、负性情绪多（OR=4.808,95％CI：2.662～8.681）、躯体需求多（0R=1.890,95％CI：1.034～3.453）和角色冲突严重（0R=1.815,95％CI：1.002～3.288）是抑郁症状的危险因素,高回报（0R=0.424,95％CI：0.226～0.796）是抑郁症状的保护因素（均P＜0.05）.有无抑郁症状组间5-HT2A受体T102C位点的基因型和等位基因的分布差异均无统计学意义（P＞0.05）;有无抑郁症状组间5-HT2A受体A-1438G位点的基因型分布差异有统计学意义（x2=9.573,P＜0.05）,但等位基因的分布差异无统计学意义（P＞0.05）.T102C位点中,高水平每日紧张感且为TC基因型或CC基因型携带者发生抑郁症状的风险分别是低水平每日紧张感且为TT基因型携带者的4.473（95％CI：1.161～17.238）、5.176（95％CI：1.367～19.593）倍,负性情绪多且为TC基因型或CC基因型携带者发生抑郁症状的风险分别是负性情绪少且为Tr基因型携带者的5.667（95％CI：1.204～26.673）、8.114（95％CI：1.747～37.677）倍;A-1438G位点中,高水平每日紧张感且为AG基因型或GG基因型携带者发生抑郁症状的风险分别是低水平每日紧张感且为AA基因型携带者的4.505（95％CI：2.215～9.162）、6.484（95％CI：2.562～16.414）倍,负性情绪多且为AG基因型或GG基因型携带者发生抑郁症状的风险分别是负性情绪少且为AA基因型携带者的4.877 （95％CI：2.326～10.223）、9.090（95％CI：3.491～23.673）倍,高回报且为AG基因型或GG基因型携带者发生抑郁Objective To investigate the association of occupational stress and 5-hydroxytryptamine 2A （5-HT2A） receptor gene polymorphisms with depression.Methods In November 2010,cluster sampling was used to select 589 workers in a thermal power plant as study subjects.Questionnaires were used to investigate demographic features and occupational stressors.Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of T102C and A-1438G in 5-HT2A receptor gene in 589 workers.Results High-level daily hassles （OR =3.013,95 % CI 1.642～5.530）,more negative emotion （OR =4.808,95%CI 2.662～8.681）,more body needs（OR=1.890,95%CI 1.034～3.453）,and severe role conflict（OR=1.815,95%CI 1.002～3.288） were risk factors for depression,while high rewards （OR=0.424,95%CI 0.226～0.796） was the protective factor against depression （all P〈0.05）.There were no significant differences in T102C genotype and allele distributions between the groups with and without depression（P〉0.05）;there was a significant difference in A-1438G genotype distribution between the groups with and without depression （x2=9.573,P〈0.05）,while there was no significant difference in A-1438G allele distribution between these groups （P〉0.05）.The risk of depression in the workers with high-level daily hassles who carried TC genotype （OR=4.473,95%CI 1.161～17.238） or CC genotype （OR=5.176,95%CI 1.367～19.593） of T102C was 4.473 and 5.176 times that in those with low-level daily hassles who carried TT genotype,and the risk of depression in the workers with more negative emotions who carried TC genotype （OR=5.667,95%CI 1.204～26.673） or CC genotype （OR=8.114,95%CI 1.747～37.677） of T102C was 5.667 and 8.114 times that in those with less negative emotion who carried TT genotype.The risk of depression in the workers with high-level daily hassles who carried AG genotype （OR=4.505,95%CI 2.215～9.162） or GG genotype （OR=6.484,95%CI 2.562～16.414） of A-1438G was 4.

关 键 词：职业应激 5-羟色胺 基因多态性 抑郁 

分 类 号：R749.4[医药卫生—神经病学与精神病学]