Neuro-rejuvenation for neuronal function  

作　　者：Yuan Liu Richard K.Lee 

机构地区：[1]Bascom Palmer Eye Institute, University of Miami School of Medicine

出　　处：《Neural Regeneration Research》2016年第10期1560-1563,共4页中国神经再生研究（英文版）

基　　金：supported by the National Glaucoma Research Program of the Bright Focus Foundation;supported by an unrestricted research grant from Research to Prevent Blindness;NIH center grant EY014801

摘　　要：Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell （RGC） death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neu- rodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation.Neurodegenerative eye diseases, such as glaucoma, cause irreversible vision loss in millions of patients worldwide, creating serious medical, economic and social issues. Like other mammalian central nervous system tracts, optic nerve intrinsically lacks the capacity for axonal growth and its surrounding environment is also non-permissive to regeneration. Any axonal damage also triggers a vicious cycle of retinal ganglion cell （RGC） death. Exploring methods that can enhance RGCs survival and promote axonal regeneration will not only enable vision restoration for millions of patients, but also shed light on the treatment of other neurodegenerative diseases. In this review article, we will go through three current approaches to cure neu- rodegenerative eye diseases, including cell based therapy, neuro-regeneration and neuro-rejuvenation.

关 键 词：neurogenerative eye disease stem cell therapy neuro-regeneration neuro-rejuvenation recoveryof vision function 

分 类 号：R741[医药卫生—神经病学与精神病学]