Parthenolide:a novel pharmacological approach to promote nerve regeneration  

作　　者：Heike Diekmann Dietmar Fischer 

机构地区：[1]Division of Experimental Neurology, Department of Neurology,Heinrich-Heine-University

出　　处：《Neural Regeneration Research》2016年第10期1566-1567,共2页中国神经再生研究（英文版）

基　　金：supported by the German Research Foundation(DFG)

摘　　要：Traumatic axonal lesions disrupt the connections between neurons and their targets, leading to loss of motoric and sensory functions. Although lesioned peripheral nerves can principally regenerate, the rate of recovery depends on the mode and severity of the respective injury （Grinsell and Keating, 2014）. While injuries close to the innervation site have good chances of recovery, long distance regeneration is particularly problematic due to relatively slow axonal growth rates, which even under favorable conditions do not normally exceed 1-2 mm per day （Sunderland, 1947）.Traumatic axonal lesions disrupt the connections between neurons and their targets, leading to loss of motoric and sensory functions. Although lesioned peripheral nerves can principally regenerate, the rate of recovery depends on the mode and severity of the respective injury （Grinsell and Keating, 2014）. While injuries close to the innervation site have good chances of recovery, long distance regeneration is particularly problematic due to relatively slow axonal growth rates, which even under favorable conditions do not normally exceed 1-2 mm per day （Sunderland, 1947）.

关 键 词：BDNF NGF 

分 类 号：R741[医药卫生—神经病学与精神病学]