Engineering personalized neural tissue using functionalized transcription factors  

作　　者：stephanie m.willerth 

机构地区：[1]department of mechanical engineering and division of medical sciences,university of victoria [2]centre for biomedical research, university of victoria [3]international collaboration on repair discoveries, university of british columbia

出　　处：《Neural Regeneration Research》2016年第10期1570-1571,共2页中国神经再生研究（英文版）

基　　金：supported by grants from the Canada Research Chairs program;the NSERC Engage and Engage Plus program

摘　　要：Diseases and disorders of the central nervous system often require significant interventions to restore lost function due to their com- plexity. Examples of such disorders include Parkinson＇s disease, Alzheimer＇s disease, multiple sclerosis, traumatic brain injury, and spinal cord in）ury. These diseases and disorders result trom healthy cells being destroyed, which in turn causes dysfunction in the cen- tral nervous system, The death of these cells can trigger a cascade of events that affect the rest of the body, causing symptoms that become progressively worse over time. Developing strategies for repairing the damage to the central nervous system remains chal- lenging, in part due to its inability to regenerate.Diseases and disorders of the central nervous system often require significant interventions to restore lost function due to their com- plexity. Examples of such disorders include Parkinson＇s disease, Alzheimer＇s disease, multiple sclerosis, traumatic brain injury, and spinal cord in）ury. These diseases and disorders result trom healthy cells being destroyed, which in turn causes dysfunction in the cen- tral nervous system, The death of these cells can trigger a cascade of events that affect the rest of the body, causing symptoms that become progressively worse over time. Developing strategies for repairing the damage to the central nervous system remains chal- lenging, in part due to its inability to regenerate.

关 键 词：CELL Engineering personalized neural tissue using functionalized transcription factors 

分 类 号：R741[医药卫生—神经病学与精神病学]