Preparation of polypyrrole-embedded electrospun poly(lactic acid) nanofibrous scaffolds for nerve tissue engineering  

作　　者：Jun-feng Zhou Yi-guo Wang Liang Cheng Zhao Wu Xiao-dan Sun Jiang Peng 

机构地区：[1]Key Laboratory of Advanced Materials of Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University,Beijing, China [2]Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China [3]School of Medicine, Nankai University, Tianjin, China [4]The Neural Regeneration Co-innovation Center of Jiangsu Province, Nantong, Jiangsu Province, China

出　　处：《Neural Regeneration Research》2016年第10期1644-1652,共9页中国神经再生研究（英文版）

基　　金：financially supported by Tsinghua University Initiative Scientific Research Program,No.20131089199;the National Key Research and Development Program of China,No.2016YFB0700802;the National Program on Key Basic Research Project of China(973 Program),No.2012CB518106,2014CB542201

摘　　要：Polypyrrole （PPy） is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly（lactic acid） （PLA） nanofibers via electrospinning and fabricated a PLA/PPy nanofibrous scaffold containing 15% PPy with sustained conductivity and aligned topog- raphy, qhere was good biocompatibility between the scaffold and human umbilical cord mesenchymal stem cells as well as Schwann cells. Additionally, the direction of cell elongation on the scaffold was parallel to the direction of fibers. Our findings suggest that the aligned PLA/PPy nanofibrous scaffold is a promising biomaterial for peripheral nerve regeneration.Polypyrrole （PPy） is a biocompatible polymer with good conductivity. Studies combining PPy with electrospinning have been reported; however, the associated decrease in PPy conductivity has not yet been resolved. We embedded PPy into poly（lactic acid） （PLA） nanofibers via electrospinning and fabricated a PLA/PPy nanofibrous scaffold containing 15% PPy with sustained conductivity and aligned topog- raphy, qhere was good biocompatibility between the scaffold and human umbilical cord mesenchymal stem cells as well as Schwann cells. Additionally, the direction of cell elongation on the scaffold was parallel to the direction of fibers. Our findings suggest that the aligned PLA/PPy nanofibrous scaffold is a promising biomaterial for peripheral nerve regeneration.

关 键 词：nerve regeneration POLYPYRROLE ELECTROSPINNING CONDUCTIVITY electrical property Schwann cells human umbilical cord mesenchymalstem cells nerve tissue engineering nanofibrous scaffolds neural regeneration 

分 类 号：R741[医药卫生—神经病学与精神病学]