幽和汤与雷贝拉唑钠肠溶片治疗Hp感染疗效观察及对比研究  

Curative Observation and Comparative Study of Using Youhe Decoction and Rabeprazole Sodium Enteric-Coated Tablets in the Treatment of Hp Infection

作　　者：周晓燕[1] 王鹏利[2] 

机构地区：[1]陕西中医药大学附属医院肿瘤二科,陕西咸阳712000 [2]陕西中医药大学附属医院普外二科,陕西咸阳712000

出　　处：《四川中医》2016年第10期114-117,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的：观察幽和汤及雷贝拉唑钠肠溶片治疗幽门螺杆菌（Hp）感染的疗效,并进行对比分析,探讨中医、西医治疗HP感染的有效性以及幽和汤是否具备替代抗生素治疗Hp感染的可行性。方法：选取2014年10月~2015年10月陕西中医药大学附属医院收治的87例患者为研究对象,随机均分为3组,分别为治疗组1、治疗组2和对照组。治疗组1：口服幽和汤,每日1剂,分2次服用,每次100ml;治疗组2：口服雷贝拉唑钠肠溶片（10mg/片）,每日2次,一次1片。对照组：口服雷贝拉唑钠肠溶片（10mg/片）,每日2次,一次1片;盐酸左氧氟沙星片（0.1g/片）,每日2次,一次2片;克拉霉素片（0.25g/片）,每日2次,一次2片;以上药物疗程均为15天。对比分析3组之间的临床疗效、HP感染根除率。结果：幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组的Hp根除率分别为31.03%、34.48%、65.52%,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2与三联疗法对照组比较,差异均有统计学意义（P〈0.05）。治疗前,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组三组间症状总积分比较,差异无统计学意义（P〉0.05）,具有可比性;治疗后幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组症状总积分均优于治疗前,差异有统计学意义（P〈0.05）,且幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2优于三联疗法对照组,组间比较差异有统计学意义（P〈0.05）。治疗后幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2及三联疗法对照组总有效率分别为89.66%、93.10%、62.07%,幽和汤治疗组1、雷贝拉唑钠肠溶片治疗组2总有效率均优于三联疗法对照组,组间比较差异有统计学意义（P〈0.05）。结论：治疗组1、治疗组2的Hp根除率均低于对照组;治疗组1、治疗组2总有效率均优于对照组;治疗组1与治疗组2比较无显著差异;幽和Objective： To observe the effect of using Youhe Decoction and rabeprazole sodium enteric-coated tablets in the treatment of helicobacter pylori（ Hp） infection and exerted comparative analysis to explore the availability of applying traditional Chinese medicine and western medicine in the treatment of HP infection and the feasibility of using Youhe Decoction to replace antibiotics in the treatment of Hp infection. Methods： 87 patients were selected of our hospital from October 2014 to October 2015 as the study objects were randomly divided into three groups,namely treatment group 1,treatment group 2and controlled group,the treatment group 1： taking orally of Youhe Decoction,one day,taken twice per 250ml; treatment groups 2： taking orally of rabeprazole sodium enteric-coated tablets（ 10 mg / tablets）,2times a day,once every time. The controlled group： taking orally of rabeprazole sodium enteric-coated tablets（ 10 mg / tablets）,2times a day,once every time; levofloxacin lactate tablets（ 0. 2g /tablet）,2times a day,two pills every time; clarithromycin dispersible tablets（ 0. 125 g / tablets）,2times a day,two pills every time,the treatment course was 15-day. SPSS20. 0software using statistical comparative analysis and comparison of the differences among the three groups,with the results（ P〈0. 05） was considered statistically significant. Results： The HP eradication rate of the treatment group 1,treatment group 2and controlled group respectively were 31. 03%,34. 48%,65. 52%,secluded combined treated group 1,rabeprazole sodium enteric-coated tablets in the treatment group 2with triple therapy group,the differences were statistically significant（ P〈0. 05））; before treatment： treated secluded combined group 1,rabeprazole sodium enteric-coated tablets in the treatment group and 2triple treatment group compared statistically,no significant difference（ P〉0. 05）,comparable treatment： treated secluded combined group 1,rabeprazole sodium enteric-coated tablets and triple t

关 键 词：幽和汤 雷贝拉唑钠肠溶片 HP感染 疗效对比 

分 类 号：R573.3[医药卫生—消化系统]