CCND1基因G870A多态性与食管癌遗传易感性的meta分析  

Meta analysis of the association between CCND1 G870A polymorphism and esophageal cancer susceptibility

作　　者：张保国[1] ZHANG Bao-guo(Department of Oncology, Nanjing Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China)

机构地区：[1]南京医科大学附属南京医院肿瘤科,江苏省南京市210006

出　　处：《实用老年医学》2016年第10期833-836,共4页Practical Geriatrics

摘　　要：目的探讨CCND1基因G870A多态性与食管癌易感性的关系。方法依据Pub Med和EMBASE数据库,检索CCND1基因G870A多态性与食管癌易感性关系的病例-对照研究,通过meta分析方法合并G870A基因型与食管癌发病风险关系的OR值,然后进行异质性分析、亚组分析和发表偏倚检验。结果纳入符合标准的文献有8项研究,共包括1252例病例和1764例对照,采用固定效应模型和随机效应模型发现,G870A在共显性和隐性模型下与食管癌的易感性有关。人群种族分层发现,在亚洲人群中,G870A多态性位点更能够增加罹患食管癌的危险性。结论 CCND1基因G870A位点多态性可能是食管癌的危险因素之一。Objective To explore the association between CCND1 gene G870 A polymorphism and esophageal cancer susceptibility by meta analysis. Methods Pub Med and EMBASE databases were used to search the case-control studies of the association between G870 A polymorphism and esophageal cancer susceptibility. In addition,OR was obtained from meta-analysis. Heterogeneity,stratified analysis,and publication bias test were also performed. Results Totally,eight case-control studies with 1252 esophageal cancer cases and 1764 controls were included in this study. A significant association was found in the codominant and recessive genetic model between G870 A polymorphism and esophageal cancer risk using fixed model or random model. Furthermore,in the subgroup of races,G870 A polymorphism was significantly associated with esophageal cancer in Asians. Conclusions CCND1 G870 A polymorphism may be one of the risk factors of esophageal cancer.

关 键 词：CCND1 食管癌 META分析 

分 类 号：R735.1[医药卫生—肿瘤]