CD11C抗体在自身免疫性肝病的表达研究  

Expression research of CD11C antibody in autoimmune liver disease

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作  者:方静怡[1] 朱正鹏[1] 李凯[1] 罗锦[1] 马建波[1] 张睿[1] 申丽娟[2] 

机构地区:[1]湖北医药学院附属东风医院病理科,湖北十堰442008 [2]昆明医科大学病理与病理生理学教研室,云南昆明650000

出  处:《临床消化病杂志》2016年第5期296-299,共4页Chinese Journal of Clinical Gastroenterology

基  金:云南省科技厅-昆明医学院联合专项(No:2011FB242)

摘  要:[目的]研究原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)及自身免疫性肝炎(autoimmune hepatitis,AIH)的病理特点,寻找有效的病理诊断指标。[方法]从2006~2012年昆明医科大学病理教研室肝穿活检病例中筛选病理诊断PBC47例[其中血清检测抗线粒体抗M2亚型(AMA—M。)阳性30例、AMA—M2阴性17例],自身免疫性肝炎(autoimmune hepatitis,AIH)20例。采用免疫组化方法检测所有病例肝组织内CD11C的表达情况。[结果]PBCAMA—M2阳性组与PBCAMA—M2阴性组CD11C阳性单位相比差异无统计学意义(P〉0.05),PBCAMA—Mz阳性组、PBCAMA—M2阴性组分别与AIH组CD11C阳性单位相比,均差异有统计学意义(P〈0.05)。[结论]CD11C主要表达于肝脏门管区肉芽肿内,有助于PBC的诊断。[Objective]To investigate the pathological features of autoimmune liver disease, explore the effective indicators of pathological diagnosis. [Methods]Liver biopsy cases during 2006 to 2012 in department of Pathology of Yunnan Kunming Medical University were screened. Totally 47 cases (thirty cases with positive serum AMA-M2, seventeen cases with negative serum AMA-M2 )were pathologically diagnosed with primary billiary cirrhosis and 20 cases were diagnosed with autoimmune hepatitis. The expression of CD11C antibodies in tissues was detected by immunohistochemestry. [Results]CD11C expression was different between the PBC group and AIH groups no matter the AMA-M2 positive or negative(P〈0.05). The CD11C expression was not different between the AMA-M2 positive and negative group(P〉0.05). [Conclusion]CD11C mainly expresses in the liver portal area granuloma which can help PBC diagnosis.

关 键 词:原发性胆汁性肝硬化 自身免疫性肝炎 CD11C 病理 诊断 

分 类 号:R575[医药卫生—消化系统]

 

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