膀胱肿瘤相关抗原在中国人群膀胱尿路上皮癌诊断中的应用  

Application of bladder tumor associated antigen in diagnosis of bladder cancer in Chinese population

作　　者：徐子程[1] 蔡宏宙[1] 喻彬[1] 须霆[1] 邹青[1] 

机构地区：[1]南京医科大学附属江苏省肿瘤医院泌尿外科,南京210009

出　　处：《临床泌尿外科杂志》2016年第10期900-902,共3页Journal of Clinical Urology

基　　金：2012年度江苏省肿瘤医院科研基金资助项目(编号ZQ201202)

摘　　要：目的:通过检测膀胱肿瘤相关抗原(BTAA)在中国人群中膀胱尿路上皮癌诊断中的敏感性及特异性,从而为早期诊断及术后随访提供更准确、更无创的诊断方式。方法:收集江苏省肿瘤医院泌尿外科病例301例,其中试验组105例,经膀胱镜活检病理确诊为膀胱尿路上皮癌;对照组为正常参加医院体检且结果提示正常的健康人群和经影像学检查或膀胱镜检查均为非膀胱尿路上皮癌患者的住院人群,共196例。检测尿液标本中BTAA含量。结果:以膀胱镜活检病理确诊为金标准检测结果,采用BTAA定量测定阳性率,阴性率分别为81.9%,88.3%。以病理恶性程度分层,低度恶性潜能尿路上皮乳头状瘤、低级别、高级别尿路上皮癌阳性率分别为58.6%、88.9%、92.5%。结论:膀胱肿瘤相关抗原是一种灵敏度强,特异性高,并且便于群体性筛查的无创性检查。有利于膀胱癌的早期诊断,对预后以及检测复发都具有重要的意义。Objective：By detecting the sensitivity and specificity of bladder tumor associated antigen（BTAA）in the diagnosis of bladder cancer in Chinese population so as to provide more accurate and noninvasive diagnostic methods for early diagnosis and postoperative follow-up.Method：We collected 301 cases,including 105 cases of the experimental group from department of urology in Jiangsu Cancer Hospital.The pathological diagnoses of bladder transitional-cell carcinomas were confirmed by biopsy of cystoscope.We tested BTAA content in urine samples.Result：The positive rate was determined by BTAA,and the negative rate was 81.9%,88.3%,respectively.The positive rates of papillary urothelial neoplasm of low malignant potential,low grade and high grade bladder transitional-cell carcinoma were 58.6%,88.9% and 92.5% respectively,which were stratified by pathological malignant degree.Conclusion：BTAA is highly sensitive,specific,and easy to be used in screening.It is helpful for early diagnosis of bladder cancer,and it has important significance in indicating prognosis and recurrence.

关 键 词：膀胱肿瘤相关抗原 膀胱肿瘤 诊断 

分 类 号：R737.14[医药卫生—肿瘤]