相转移催化合成香料烟酮及中间体异佛尔酮  

Synthesis of 2-Hydroxy-3,5,5-trimethyl-2-cyclohexenone and Intermediate Isophorone by Using Phase Transfer Catalyst

作　　者：舒学军[1] 朱百鸣 宋才生[1] 

机构地区：[1]江西师范大学化学系 [2]江西省环境保护研究所,南昌330027

出　　处：《化学通报》2002年第8期560-562,共3页Chemistry

基　　金：江西省二级重点项目 (19990 5 2 4 );帝博香料公司资助项目

摘　　要：报道了香料烟酮 (2 羟基 3 ,5 ,5 三甲基 2 环戊烯酮 )及中间体异佛尔酮的合成 ,首先用 4 甲基 3 戊烯 2 酮和乙酰乙酸乙酯 ,在相转移催化剂Et3 N+ CH2 PhCl-和EtONa EtOH条件下合成中间体异佛尔酮 ,异佛尔酮在碱性条件下被H2 O2 氧化成 2 ,3 环氧异佛尔酮 ,2 ,3 环氧异佛尔酮在酸性条件下反应生成烟酮 ,对烟酮的IR ,1HNHR谱进行了分析。Hydroxy 3,5,5 trimethyl 2 cyclohexenone and the intermediate isophorone were synthesized.First, 4 methyl 3 penten 2 one reacted with ethyl acetylacetate in the presenec of under EtONa/EtOH to convert into isophorone. Second, isophorone was oxidated into isophorone oxide(2,3 epoxyisophorone) by H 2O 2 under alkaline condition. Then the isophorone oxide under acidic condition was converted into 2 hydroxy 3,5,5 trimethyl 2 cyclohexenone,and its 1H NMR, IR spectra were discussed.

关 键 词：相转移催化合成 香料 烟酮 中间体 2-羟基 -3 5 5-三甲基-2-环戊烯酮 异佛尔酮 环化缩合 

分 类 号：O643.3[理学—物理化学]