颈动脉狭窄程度对急性脑梗死患者神经功能及血浆纤维蛋白原水平的影响研究  

Impact of Severity of Carotid Artery Stenosis on Neurological Function and Plasma Fibrinogen Level of Patients with Acute Cerebral Infarction

作　　者：郭俊华[1] 陆小波[1] 刘彩玲[1] 

机构地区：[1]江苏省泰州市第二人民医院神经内科,225500

出　　处：《实用心脑肺血管病杂志》2016年第10期33-36,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨颈动脉狭窄程度对急性脑梗死(ACI)患者神经功能及血浆纤维蛋白原水平的影响。方法选取2013—2015年泰州市第二人民医院神经内科收治的ACI患者200例,根据颈动脉狭窄程度分为无狭窄组40例、轻度狭窄组107例、中度狭窄组30例、重度狭窄组23例。4组患者入院后均行多普勒超声检查,采用美国国立卫生研究院卒中量表(NIHSS)和格拉斯哥昏迷量表(GCS)评估4组患者神经功能缺损程度,测定血浆纤维蛋白原水平。比较4组患者NIHSS评分、GCS评分、脑梗死体积及血浆纤维蛋白原水平。结果 4组患者NIHSS评分比较,差异有统计学意义(P<0.05),且组间两两NIHSS评分比较,差异均有统计学意义(P<0.05);4组患者GCS评分比较,差异无统计学意义(P>0.05)。Spearman秩相关性分析结果显示,颈动脉狭窄程度与NIHSS评分呈正相关(rs=0.66,P=0.00)。4组患者脑梗死体积比较,差异有统计学意义(P<0.05);组间两两脑梗死体积比较,差异均有统计学意义(P<0.05)。Spearman秩相关性分析结果表明,颈动脉狭窄程度与脑梗死体积呈正相关(rs=0.93,P=0.00)。4组患者血浆纤维蛋白原水平比较,差异有统计学意义(P<0.05);组间两两血浆纤维蛋白原水平比较,差异均有统计学意义(P<0.05)。Spearman秩相关性分析结果显示,颈动脉狭窄程度与血浆纤维蛋白原水平呈正相关(rs=0.76,P=0.00)。结论 ACI患者颈动脉狭窄程度越严重,神经功能缺损程度越严重,血浆纤维蛋白原水平越高,脑梗死进展越快。Objective To investigate the impact of severity of carotid artery stenosis on neurological function and plasma fibrinogen level of patients with acute cerebral infarction. Methods From 2013 to 2015,a total of 200 patients with acute cerebral infarction were selected in the Department of Neurology,the Second People＇s Hospital of Taizhou,and they were divided into A group（ without carotid artery stenosis,n = 40）,B group（ with mild carotid artery stenosis,n = 107）,C group（ with moderate carotid artery stenosis,n = 30） and D group（ with severe carotid artery stenosis,n = 23） according to the severity of carotid artery stenosis. All of patients received Doppler ultrasonography examination after admission,National Institutes of Health Stroke Scale（ NIHSS） and Glasgow Coma Scale（ GCS） were used to evaluate the degree of nervous functional defects,and the plasma fibrinogen level was detected. NIHSS score, GCS score, infarct volume and plasma fibrinogen level were compared among the four groups. Results There was statistically significant difference of NIHSS score among the four groups（ P〈0. 05）,so was between any two groups（ P〈0. 05）,while no statistically significant differences of GCS score was found among the four groups（ P〈0. 05）; Spearman correlation analysis results showed that,the severity of carotid artery stenosis was positively correlated with NIHSS score（ rs= 0. 66,P = 0. 00）. There was statistically significant difference of infarct volume among the four groups（ P〈0. 05）,so was between any two groups（ P〈0. 05）; Spearman correlation analysis results showed that,the severity of carotid artery stenosis was positively correlated with infarct volume（ rs= 0. 93, P = 0. 00）. There was statistically significant difference of plasma fibrinogen level among the four groups（ P〈0. 05）,so was between any two groups（ P〉0. 05）. Spearman correlation analysis results showed that,the severity of carotid artery stenosis was positively correlated with pla

关 键 词：脑梗死 颈动脉狭窄 神经功能缺损 纤维蛋白原 

分 类 号：R743.33[医药卫生—神经病学与精神病学]