Thermal and Redox Dual Responsive Poly(L-glutamate)with Oligo(ethylene glycol)Side-chains  

作　　者：Xiao-hui Fu Yi-nan Ma 孙静 李志波 

机构地区：[1]School of Polymer Science and Engineering, Qingdao University of Science and Technology [2]Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences

出　　处：《Chinese Journal of Polymer Science》2016年第12期1436-1447,共12页高分子科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.20974112 and 50821062)

摘　　要：A series of poly（L-glutamate）s grafted with oligo（ethylene glycol） （OEG） side-chains through the thioether linkages （PALGn-g-EGx, x = 2, 3 and 4） were prepared by ring-opening polymerization （ROP） of γ-allyl-L-glutamate N-carboxyanhydride （ALG-NCA） and thiol-ene photoaddition. The chemical structures and physical properties were characterized by 1H-NMR, Fourier transform infrared （FTIR）, circular dichroism （CD）, etc. The PALGn-g-EGx samples with x = 3 and 4 displayed lower critical solution temperature （LCST） in water due to the presence of OEG units. The clouding point （CP） of polypeptides can be finely tuned by changing the side chain structures, molecular weights and sample concentrations. In addition, the thioether linkages in the side chains offer additional redox-responsive properties. The influence of both OEG units and thioether linkages on the LCST behavior was systematically investigated. This work provides an efficient way to prepare multi-stimuli responsive materials with highly tunable properties.A series of poly（L-glutamate）s grafted with oligo（ethylene glycol） （OEG） side-chains through the thioether linkages （PALGn-g-EGx, x = 2, 3 and 4） were prepared by ring-opening polymerization （ROP） of γ-allyl-L-glutamate N-carboxyanhydride （ALG-NCA） and thiol-ene photoaddition. The chemical structures and physical properties were characterized by 1H-NMR, Fourier transform infrared （FTIR）, circular dichroism （CD）, etc. The PALGn-g-EGx samples with x = 3 and 4 displayed lower critical solution temperature （LCST） in water due to the presence of OEG units. The clouding point （CP） of polypeptides can be finely tuned by changing the side chain structures, molecular weights and sample concentrations. In addition, the thioether linkages in the side chains offer additional redox-responsive properties. The influence of both OEG units and thioether linkages on the LCST behavior was systematically investigated. This work provides an efficient way to prepare multi-stimuli responsive materials with highly tunable properties.

关 键 词：N-carboxyanhydride （NCA） POLYPEPTIDE Ring-opening polymerization Click chemistry Stimuli-responsive. 

分 类 号：O631.5[理学—高分子化学]