肿瘤坏死因子受体相关因子6在食管癌组织中的表达及意义  

Expression of tumor necrosis factor receptor associated factor 6 in human esophageal carcinoma and its clinical significance

作　　者：郑天亮[1] 赵松[1] 郭海周[1] 崔广晖[1] 

机构地区：[1]郑州大学第一附属医院胸外一科,河南省郑州450052

出　　处：《中国基层医药》2016年第22期3437-3440,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的：探讨肿瘤坏死因子受体相关因子6（TRAF6）在食管癌组织中的表达及临床意义。方法收集72例食管癌患者的临床资料，采用免疫组织化学方法测定 TRAF6在食管癌及其癌旁正常组织中的表达，并探讨其与临床病理特征的关系。结果 TRAF6在食管癌组织中阳性表达率为66．13％，显著高于正常组织中的13．89％，差异有统计学意义（χ2＝56．850，P ＜0．01），TRAF6表达水平与食管癌临床分期、淋巴结转移存在明显相关性（χ2＝6．818、4．428，均 P ＜0．05）；但其与年龄、性别、肿瘤分化程度无明显相关性。结论TRAF6在食管癌中的表达水平明显升高，且与患者临床病理特征存在明显相关性。Objective To investigate the expression and clinical significance of tumor necrosis factor recep-tor associated factor 6（TRAF6）in human esophageal cancer.Methods The clinical data of 72 patients with esopha-geal cancer were collected.Immunohistochemistry method was used to determine TRAF6 expression in esophageal carcinoma and its adjacent normal tissue,and its relationship with clinical pathological features was explored.Results The TRAF6 positive expression rate in esophageal cancer tissue was 66.13%,which was significantly higher than that of normal tissue （13.89%）,the difference between the two groups was statistically significant（χ2 =56.850,P 〈0.01）.And TRAF6 expression level was significantly correlated with esophageal cancer clinical staging,lymph node metastasis（χ2 =6.818,4.428,all P 〈0.05）,but TRAF6 expression was not correlated with age,sex,tumor differenti-ation.Conclusion The expression level of TRAF6 in esophageal carcinoma was significantly increased,and there was a significant correlation between the TRAF6 expression level and clinical pathological characteristics.

关 键 词：食管肿瘤 肿瘤坏死因子受体相关肽和相关蛋白质类 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]