伊托必利及黛力新合用治疗功能性消化不良的临床有效性综合评价  

Efficacy of Itopride combined Deanxit in the treatment of functional dyspepsia

作　　者：叶曼玲[1] 

机构地区：[1]自贡市第一人民医院消化内科,四川自贡643000

出　　处：《中国中西医结合消化杂志》2016年第10期768-770,775,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]探讨伊托必利联合黛力新治疗功能性消化不良(FD)的临床有效性和安全性。[方法]纳入216例FD患者,随着分为试验组108例和对照组108例,前者采用伊托必利联合黛力新治疗,后者采用伊托必利治疗,治疗4周后,采用χ2检验比较消化道症状和抑郁症状的疗效。[结果]试验组的总有效率为92.59%,显著高于对照组的82.41%(χ2=4.738,P=0.030);治疗后试验组焦虑抑郁症状严重程度的分布有显著变化(χ2=20.270,P<0.001),而对照组无明显改变(χ2=5.024,P=0.170),试验组的症状严重程度分布与对照组比较,差异有统计学意义(χ2=9.428,P=0.024);2组不良反应发生率比较差异无统计学意义(P>0.05)。[结论]伊托必利联合黛力新对FD的消化道症状和抑郁症状安全有效,值得临床推广应用。[Objective]To explore the efficacy of Itopride combined Deanxit in the treatment of functional dyspepsia（FD）.[Methods]A total of 216 FD patients were randomly divided into experimental group of108 cases and control group of 108 cases.The experimental group received Itopride combined Deanxit therapy,and the control group received Itopride treatment.After 4weeks of treatment,the efficacy of gastrointestinal symptoms and depressive symptoms were compared between the two groups.t.[Results]The total effective rate of the experimental group was 92.59%,which was significantly higher than 82.41%in control group（χ^2=4.738,P=0.030）.After treatment,the severity distributions of anxiety and depression symptoms in the experimental group changed significantly（χ^2=20.270,P〈0.001）,while there was no significant change in the control group（χ^2=5.024,P=0.170）.The symptom severity distributions of the experimental group were significantly different from control group（χ^2=9.428 and the control group,P=0.024）.There was no significant difference in the incidence of adverse reactions between the two groups（P〉0.05）.[Conclusion]Itopride combining deanxit is effective and safe for gastrointestinal symptoms and depressive symptoms in FD patients.

关 键 词：伊托必利 黛力新 功能性消化不良 

分 类 号：R573[医药卫生—消化系统]