降糖药米格列奈钙的合成  

Synthesis of Mitiglinide Calcium of The Antidiabetic Medicine

作　　者：李纬 王正泽 林辉 

机构地区：[1]南京长澳医药科技有限公司,江苏南京210038

出　　处：《山东化工》2016年第20期19-21,共3页Shandong Chemical Industry

摘　　要：以(1S,2R)-(-)-樟脑磺内酰胺为原料,经氨解、不对称烷基化、水解、缩合、水解,成盐6步反应得到米格列奈钙。获得的米格列奈钙纯度高,总收率59.7%。该方法工艺简单,适合工业化生产。Objective： To synthesis mitiglinide calcium. Methods： Starting from（1S,2R）-（-）-2,10-camphorsultamc,mitiglinide calcium was obtained via six-step reactions including ammonolysis, asymmetric alkylation, hydrolyzation,condensation,hydrolyzation,salt formation. Result and Conclusion： Mitiglinide calcium of high purity is obtained and the overall yield was 59. 7%. The process was simple and suitable for the industrialized production.

关 键 词：米格列奈钙 合成工艺 降糖药 

分 类 号：R914.5[医药卫生—药物化学]