发作性睡病发病机制的研究进展  

Advance in Etiopathogenesis of Narcolepsy

作　　者：郝茂林[1] 郝苗清[1] 杜怡峰[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250022

出　　处：《医学综述》2016年第21期4233-4237,共5页Medical Recapitulate

摘　　要：发作性睡病是一种慢性睡眠障碍性疾病,严重影响患者的生活质量。其临床症状包括日间过度睡眠、猝倒发作、睡前幻觉和睡眠瘫痪等。自该病发现至今已有100多年,但近年科学家才阐明其发病机制。Ⅰ型发作性睡病是由易患个体经免疫介导下视丘分泌素神经元丢失造成的;猝倒发作和过度睡眠的神经机制也越来越清晰,而Ⅱ型发作性睡病的发病机制尚不清楚。Narcolepsy is a chronic lifeiong sleep disorder and it often leaves a debilitating effect on the quality of life of the sufferer. This disorder is charaeterlzed by a tetrad of excessive daytime sleepiness, cata- plexy, hypnogogic hallucinations and sleep paralysis. For over 100 years, clinicians have recognized narcolepsy, but only in the last few decades have scientists been able to shed light on the true cause and pathogenesis of narcolepsy. In the majority of subjects, type I narcolepsy is caused by autoimmune-mediated loss of hypocre- tin-secreting neurons in genetically predisposed individuals. The basic neural mechanisms behind sleepiness and cataplexy,the two defining symptoms of narcolepsy have started to become clearer. The pathophysiology of twe Ⅱ narcolepsy is less well understood.

关 键 词：发作性睡病 猝倒发作 下视丘分泌素 人类白细胞抗原 快速眼动睡眠 

分 类 号：R743[医药卫生—神经病学与精神病学]