药物卵巢去势联合化疗在可手术乳腺癌患者中应用研究  

Application of drug ovarian castration combined with chemotherapy in patients with operable breast cancer

作　　者：周伟清[1] 庄一心[1] 

机构地区：[1]复旦大学附属中山医院青浦分院普外科,上海201700

出　　处：《西南国防医药》2016年第11期1248-1250,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探讨药物卵巢去势联合化疗在可手术乳腺癌患者中的应用价值。方法选择81例可手术治疗的乳腺癌患者,随机分为手术组、化疗组与联合组各27例。3组均予手术治疗,化疗组、联合组术后分别加用化疗及化疗联合戈舍瑞林治疗。治疗后每6个月检查卵泡刺激素(FSH)、雌二醇(E2),用彩超测定卵巢间质血流峰值流速(PSV)及阻力指数(RI)。结果(1)化疗组、联合组总有效率高于手术组,但仅联合组与手术组对比有统计学差异(P<0.05);(2)治疗后6个月,各组FSH、E2均降低,联合组、化疗组降幅低于手术组(P<0.05),且联合组FSH、E2低于化疗组(P<0.05);治疗12个月,化疗组FSH、E2与治疗6个月对比差异无统计学意义(P>0.05),手术组FSH、E2降低,联合组上升(P<0.05);(3)治疗后6、12个月,各组PSV下降、RI上升(P<0.05),化疗组和联合组变化幅度大于手术组(P<0.05),联合组变化幅度大于化疗组(P<0.05)。结论戈舍瑞林药物去势联合化疗可提高乳腺癌治疗效果,改善患者卵巢功能。Objective To explore the application value of drug ovarian castration combined with chemotherapy in patients with operable breast cancer. Methods A total of 81 patients with operable breast cancer were selected and randomly divided into an operation group, a chemotherapy group and a combination group（n=27, respectively）. The three groups were treated with operation.The chemotherapy group and the combination group were further treated with chemotherapy and chemotherapy combined with goserelin after the operation respectively. The FSH and E2 were detected every six months after the treatment. Ovarian stroma PSV and RI were detected with Color Doppler Ultrasound. Results（1）The ORR in the chemotherapy group and the combination group were higher than that in the operation group, but there was statistical difference between the combination group and the operation group（P〈0.05）;（2）Six months after the treatment, the FSH and E2 in the three groups decreased; the decrease in the combination group and the chemotherapy group was less than that in the operation group（P〈0.05）, and the FSH and E2 in the combination group were lower than that in the chemotherapy group（P〈0.05）. 12 months after the treatment, there was no statistical difference between the FSH and E2 in the chemotherapy group and those six months after the treatment（P〈0.05）, and the FSH and E2 decreased in the operation group and increased in the combination group（P〈0.05）;（3）6 and 12 months after the treatment, the PSV decreased and RI increased in the three groups（P〈0.05）, the extend of change in the chemotherapy group and the combination group was greater than that in the operation group（P〉0.05）, and the extend of change in the combination group was greater than that in the chemotherapy group（P〈0.05）. Conclusion Goserelin medical castration combined with chemotherapy can improve the efficacy on the treatment of breast cancer and the ovarian function of patients.

关 键 词：乳腺癌 卵巢去势 化疗 疗效 手术治疗 

分 类 号：R737.9[医药卫生—肿瘤]