斯钙素的生物学特征及其与人体肿瘤关系研究进展  

The progress of the research on the relationship between stanniocalcins and cancers

作　　者：杨舒雯[1] 马奔[1] 周力[1] 王宇[1] 

机构地区：[1]复旦大学附属肿瘤医院头颈外科,复旦大学上海医学院肿瘤学系,上海200032

出　　处：《中国癌症杂志》2016年第10期875-880,共6页China Oncology

摘　　要：斯钙素(stanniocalcin,STC)是一种糖蛋白激素,由鱼类独有的内分泌腺斯坦尼小体所分泌。在哺乳动物中,也存在STC样蛋白,分别命名为STC-1和STC-2,通过肾脏和胃肠道来调节钙和磷酸盐的代谢,STC-1与鱼类STC氨基酸序列显示高度同源性(约50%),STC-2则较低,有35%左右的氨基酸呈同源性。一些研究已发现它们的细胞定位、基因结构在不同的生理和病理情况下的表达,为阐明哺乳动物的STC功能提供线索。此外,STC-1和STC-2在众多肿瘤细胞系中有表达,提示哺乳动物STC具有除矿物质代谢外的多种生物学功能。Stanniocalcin （STC） was first found as a calcium- and phosphate-regulating hormone produced in bony fish by the corpuscles of Stannius. In mammals, the homolog STC-1 displays a relative high amino acid sequence identity （nearly 50%） with fish STC, and STC-2 has a lower identity （nearly 35%） with STC-1 and fish STC. Both STC-1 and STC-2 are expressed in a variety of tissues. The functions of STC have not been understood. But some findings have been reported on their cellular localization, gene structure, and expression in different physiological and pathological conditions, which will be clues in elucidating the functions of STC in mammals. Moreover, STC-1 and STC-2 are expressed in many tumor cell lines, suggesting other biological functions of STC in mammals other than mineral metabolism.

关 键 词：斯钙素 肿瘤 细胞增殖 肿瘤微环境 

分 类 号：R73-37[医药卫生—肿瘤]