间充质干细胞对肿瘤血管生成的影响  

Effects of mesenchymal stem cells on angiogenesis of tumor

作　　者：韩昌敏 张雷[1] 吴启龙[1] 李宝平[1] 

机构地区：[1]山西医科大学第二医院肿瘤生物治疗科,太原030001

出　　处：《中华细胞与干细胞杂志（电子版）》2016年第4期252-257,共6页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：间充质干细胞(MSC)是一类具有自我更新、多向分化潜能和损伤趋化的多能干细胞。在一定诱导条件下MSC可以分化为骨、软骨、肌肉和血管内皮等组织,常将其应用于组织修复和心肌缺血等其他缺血性疾病的实验研究及临床应用中。由于MSC具有向肿瘤间质的"损伤趋化性",在过去的十几年,将其作为携带治疗基因的合适载体用于肿瘤治疗研究。而进一步研究发现趋化至肿瘤间质的MSC与肿瘤微环境相互作用可分化为血管内皮、血管周细胞等,或者通过旁分泌等各种机制对肿瘤血管生成产生影响。但是在不同的肿瘤模型中,MSC对肿瘤血管生成的影响存在争议,这篇综述旨在探讨影响实验结果的相关因素,综合分析认为:MSC可以促进肿瘤血管结构和功能的完整性,修复肿瘤血管,这在针对肿瘤血管生成治疗尤其是联合其他治疗方法来治疗肿瘤显示出很大潜力。Mesenchymal stem cell （MSC） are multipotent stem cells that are capable of self-renewal, multilineage differentiation and chemotactic. In addition to bone, cartilage, muscle, it has been demonstrated that MSC are capable of differentiating into vascular endothelial cells under certain conditions. So they are currently being explored for tissue repair, myocardial ischemia and other ischemic diseases. MSC can be recruited into tumor and they have been considered as the potential vehicles for cell-based gene therapy. MSC interact with tumor micro-environment by differentiating into endothelial cells, perithelial cells or paracrine mechanism. But in different tumor models, the influence of MSC on tumor angiogenesis is controversial. This review aimed to explore the factors that may affect the experiments results.

关 键 词：间质干细胞 肿瘤 血管生成 

分 类 号：R730.2[医药卫生—肿瘤]