Towards Personalized Intervention for Alzheimer's Disease  

作　　者：Xing Peng Peiqi Xing Xiuhui Li Ying Qian Fuhai Song Zhouxian Bai Guangchun Han Hongxing Lei 

机构地区：[1]CAS Key Laboratory of Genome Sciences and Information,Beijing Institute of Genomics,Chinese Academy of Sciences [2]Cunji Medical School,University of Chinese Academy of Sciences [3]Center of Alzheimer’s Disease,Beijing Institute for Brain Disorders

出　　处：《Genomics, Proteomics & Bioinformatics》2016年第5期289-297,共9页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National High-tech R&D Program of China (863 Program;Grant No.2015AA020108);the National Basic Research Program of China (973 Program;Grant No.2014CB964901) funded by the Ministry of Science and Technology of China

摘　　要：Alzheimer＇s disease （AD） remains to be a grand challenge for the international community despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the disease etiology, which involves very complex and divergent pathways. Therefore, intervention strategies shall be tailored for subgroups of AD patients. Both demographic and in-depth information is needed for patient stratification. The demographic information includes primarily APOE genotype, age, gender, education, environmental exposure, life style, and medical history, whereas in-depth information stems from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripotent cells （iPSCs）. Comprehensive information collection, better understanding of the disease mech- anisms, and diversified strategies of drug development would help with more effective intervention in the foreseeable future.Alzheimer＇s disease （AD） remains to be a grand challenge for the international community despite over a century of exploration. A key factor likely accounting for such a situation is the vast heterogeneity in the disease etiology, which involves very complex and divergent pathways. Therefore, intervention strategies shall be tailored for subgroups of AD patients. Both demographic and in-depth information is needed for patient stratification. The demographic information includes primarily APOE genotype, age, gender, education, environmental exposure, life style, and medical history, whereas in-depth information stems from genome sequencing, brain imaging, peripheral biomarkers, and even functional assays on neurons derived from patient-specific induced pluripotent cells （iPSCs）. Comprehensive information collection, better understanding of the disease mech- anisms, and diversified strategies of drug development would help with more effective intervention in the foreseeable future.

关 键 词：Alzheimer＇s disease Demographic information GENOME Peripheral biomarkers iPSC technology 

分 类 号：R749.16[医药卫生—神经病学与精神病学]