Ⅱ型食管胃连接处腺癌术后纵隔淋巴结复发或转移的相关因素分析  

Risk factors analysis associated with recurrence or metastasis of mediastinal lymph nodes in patients with type Ⅱ adenocarcinoma of esophageal and gastric junction after resection

作　　者：黄永高[1] 陈霞[1] 王鹏程[1] 贾卫光 

机构地区：[1]泰州市人民医院胸心外科,江苏泰州225300

出　　处：《江苏大学学报（医学版）》2016年第5期415-417,421,共4页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨Ⅱ型食管胃连接处腺癌(adenocarcinoma of esophagogastric junction,AEG)根治性切除术后纵隔淋巴结复发或转移的独立危险因素。方法:回顾性分析在我院行根治性切除(R0切除)的353例Ⅱ型AEG患者的临床资料,分析术后纵隔淋巴结复发或转移的相关危险因素。结果:Ⅱ型AEG患者R0切除后纵隔淋巴结复发或转移率为12.5%(44/353),单因素分析表明,脉管侵犯、肿瘤分化程度、N分期、肿瘤近端到食管胃交界距离(≥2.5 cm)是Ⅱ型AEG术后纵隔淋巴结复发或转移的可能相关因素;多因素分析表明,肿瘤分化程度(低分化)、肿瘤近端到食管胃交界距离(≥2.5 cm)是Ⅱ型AEG术后纵隔淋巴结复发或转移的独立危险因素。结论:肿瘤分化程度、肿瘤近端到食管胃交界距离(≥2.5 cm)是预测Ⅱ型AEG患者R0切除术后纵隔淋巴结复发或转移的独立危险因素。Objective：To investigate risk factors of mediastinal lymph node metastasis or recurrence of typeⅡadenocarcinoma of esophagogastric junction（AEG）after radical resection.Method：We retrospectively analyzed the clinical data of 353 patients with type AEGⅡwho underwent radical resection （R0 resection）in our hospital.The risk factors of recurrence or metastasis of mediastinal lymph nodes were analyzed.Results：The overall rates of metastasis or recurrence of typeⅡAEG after operation was 1 2.5%（44/353）.Univariate analysis showed that the histological grade,vascular invasion,N stage and distance from the esophagogastric junction（EGJ）to the proximal edge of primary tumor （≥2.5 cm）were the potential factors related to the me-tastasis or recurrence of the mediastinal lymph nodes after operation（P〈0.05）.Logistic multivariate regression analysis showed that distance from EGJ to the proximal edge of primary tumor （≥2.5 cm）and histological grade were independently related with the metastasis or recurrence of the mediastinal lymph nodes （P 〈0.05 ）. Conclusions：The distance from the EGJ to the proximal edge of primary tumor （≥2.5 cm）and histological grade are independent factors of predicting the metastasis or recurrence of the mediastinal lymph nodes after R0 resection for typeⅡAEG.

关 键 词：食管胃连接处腺癌 淋巴结 转移或复发 危险因素 

分 类 号：R735.1[医药卫生—肿瘤]