消化系统恶性肿瘤miRNA与lncRNA研究进展  

MicroRNAs and long non-coding RNAs in digestive system malignancies

作　　者：任美萍 罗茂 

机构地区：[1]西南医科大学药物研究中心,四川省泸州市646000

出　　处：《世界华人消化杂志》2016年第29期4048-4057,共10页World Chinese Journal of Digestology

基　　金：四川省卫生厅基金资助项目;No.120371;四川省教育厅基金资助项目;No.16ZA0178;泸州市科技局基金资助项目;Nos.2013-S-47;2013LZLY-K64~~

摘　　要：哺乳动物基因组转录后存在大量微小RNA(microRNA,miRNA)和长链非编码RNA(long noncoding RNA,lncRNA).研究显示,部分常见的功能性miRNA和lncRNA与消化系统肿瘤关系密切,他们在肿瘤的发生、发展过程中发挥着重要调控作用,与患者临床预防、诊疗及预后密切相关.本文综述了近年来消化系统恶性肿瘤miRNA与lncRNA的研究进展,探讨miRNA与lncRNA发挥的促癌或者抑癌作用及其表观遗传学机制,展望他们作为消化系统恶性肿瘤潜在的诊断标志物或治疗靶点的广阔临床前景,将为当前消化系统肿瘤的预防、诊疗和预后提供新思路.The mammalian transcriptome includes a large number of microRNAs（miRNAs） and long non-coding RNAs（lncRNAs）. Some studies have reported that numerous kinds of miRNAs and lncRNAs have been implicated in playing key regulatory roles in the occurrence and development of digestive system malignances.Therefore, they are closely related to the clinical diagnosis, treatment and prognosis of digestive system malignances. This review focuses on the recent progress in research of miRNAs and lncRNAs in in digestive system malignancies and discusses their epigenetics roles as oncogenes or tumor suppressors. The current and future potential clinical applications of miRNAs and lncRNAs in digestive system malignancies are also discussed, with an aim to provide new ideas and means for the diagnosis,treatment and prognosis of digestive system malignancies.

关 键 词：MIRNA lncRNA 消化系统恶性肿瘤 表观遗传学机制 生物标志物 

分 类 号：R735[医药卫生—肿瘤]