磁共振体素内不相干运动成像在大鼠肝纤维化模型中的应用  

Magnetic Resonance Imaging of Intravoxel Incoherent Motion in Rats Hepatic Fibrosis

作　　者：胡根文[1] 全显跃[2] Queenie Chan 李余发[4] 林婷[2] 史达[2] 

机构地区：[1]深圳市宝安区妇幼保健院影像中心,广东深圳518133 [2]南方医科大学珠江医院影像中心,广东广州510282 [3]飞利浦医疗保健事业部,香港999077 [4]南方医科大学珠江医院病理科,广东广州510282

出　　处：《中国医学影像学杂志》2016年第9期658-661,共4页Chinese Journal of Medical Imaging

基　　金：广东省医学科学技术研究基金(B2016025)

摘　　要：目的探讨磁共振体素内不相干运动(IVIM)成像在肝纤维化进程中的变化规律。材料与方法选取65只SD大鼠,分为对照组15只和模型组50只,模型组采用四氯化碳诱导不同时间以获取不同程度的肝纤维化。使用3.0T MR进行肝脏IVIM成像获得体素内真性水分子扩散(D)、灌注分数(f)、体素内微循环灌注(D*)。扫描后行病理检查并分为对照组及轻度、中度、重度肝纤维化组,将影像学表现与病理结果进行对照。结果对照组15只大鼠和模型组42只大鼠完成实验,不同程度肝纤维化组IVIM参数D、f、D*值比较,差异均有统计学意义(F=17.58、13.80、27.48,P<0.05);肝纤维化程度与D、f、D*均呈负相关(r=-0.668、-0.630、-0.704,P<0.05)。结论 IVIM可以作为一种无创的、不使用造影剂的新技术用于探测肝纤维化进程中组织内扩散和灌注的变化,反映肝纤维化早期的病理生理改变,有助于早期检测和诊断肝纤维化。Purpose To explore MRI intravoxel incoherent motion（IVIM） in progress of rats hepatic fibrosis which is induced by carbon tetrachloride. Materials and Methods Sixty-five rats were divided into 50 rats of model group and 15 rats of control group. Fifty treated rats were induced by carbon tetrachloride for different times to obtain different degrees of hepatic fibrosis. 3.0T MR was performed to obtain IVIM parameters pure molecular diffusion（D）, perfusion fraction（f）, perfusion related diffusion（D＊）. Hepatic pathological analysis was performed after MR scanning, and were further divided into four groups（normal, mild, moderate, severe hepatic fibrosis）. Then the imaging and histopathological manifestation were compared. Results There was significant differences among four groups in D, f, D＊ values（F=17.58, 13.80 and 27.48, P〈0.05）. D, f and D＊ values were negatively correlated with hepatic fibrosis levels（r=- 0.668,- 0.630 and- 0.704, P〈0.05）. Conclusion IVIM may be a new noninvasive technique without contrast agent to investigate changes of tissue diffusion and perfusion in the progress of hepatic fibrosis, as well as early patho-physiological changes, which can contribute to diagnose hepatic fibrosis at the early stage.

关 键 词：肝硬化 磁共振成像 弥散 扩散加权成像 病理学 疾病模型 动物 大鼠 Sprague-Dawley 

分 类 号：R-33[医药卫生] R445.2