MMP21 MMP28与胃癌进展及不良预后的相关性研究  

作　　者：颜文辉 马杰[2] 

机构地区：[1]浙江省温岭市中医院病理科,317500 [2]浙江省人民医院病理科,310014

出　　处：《浙江临床医学》2016年第11期1985-1987,共3页Zhejiang Clinical Medical Journal

摘　　要：目的：观察人胃癌组织MMP21和MMP28的表达，探讨其与临床病理特征和预后的关系。方法应用免疫组化法检测436例胃癌组织和92例癌旁胃组织MMP21和MMP28的表达，分析其与胃癌进展及不良预后的相关性。结果在胃癌组织中，MMP21、MMP28的阳性检出率分别为31.9%（139/436）和34.4%（150/436）；而92例癌旁胃组织中，MMP21、MMP28均为阴性。在胃癌组织中，MMP21和MMP28的阳性表达与肿瘤大小、浸润深度、血管侵袭、淋巴结、远处转移及TNM分期相关。总生存率在阳性患者比阴性患者低。Cox多因素分析表明在胃癌患者中MMP21、MMP28是生存的独立预测因素。结论 MMP21、MMP28与胃癌的侵袭、转移和预后密切相关，其可能成为新的、独立的预后指标。Objective To observe the expression of MMP21 and MMP28 in gastric cancer tissues, and explore their relationship with clinical pathological feature and prognosis. Methods The expression was detected by immunohistochemical in 436 cases of gastric carcinoma and 92 cases of adjacent gastric tissue with MMP21 and MMP28, and we analyzed their correlation with the progression and poor prognosis of gastric cancer. Results The positive rate of MMP21 and MMP28 in gastric cancer tissues was 31.9% （ 139/436 ） and 34.4% （ 150/436 ） ; but they were negative in 92 cases of adjacent normal gastric tissues. The positive expression of MMP21 and MMP28 related to tumor size, infiltration depth, lymph vascular invasion, node metastasis and TNM staging. The total survival rate in positive patients lower than negative patients. Cox multivariate analysis showed that MMP21 and MMP2 were independent predictors of survival in patients with gastric cancer. Conclusion MMP21 and MMP28 closely contact with invasion, metastasis and prognosis, and they may become new and independent prognostic indicators in gastric cancer.

关 键 词：MMP21 MMP28 胃癌 肿瘤进展 预后 

分 类 号：R735.2[医药卫生—肿瘤]