经颅磁刺激联合尼莫地平和多奈哌齐治疗血管性痴呆的疗效观察  

The effect of transcranial magnetic stimulation combined with nimodipine and donepezil on the treatment of vascular dementia

作　　者：李小莹[1] 张瑭 

机构地区：[1]第四军医大学第三附属医院老年病科,陕西西安710032

出　　处：《临床医学研究与实践》2016年第23期56-57,共2页Clinical Research and Practice

摘　　要：目的探讨经颅磁刺激技术(TMS)联合尼莫地平和多奈哌齐治疗血管性痴呆的临床疗效。方法选取80例血管性痴呆患者为研究对象,随机分为TMS联合药物治疗组(42例)与药物治疗组(38例)。两组患者均给予常规治疗,药物治疗组在常规治疗的同时给予尼莫地平和多奈哌齐;TMS联合药物治疗组在在此基础上加用TMS治疗。对比两组患者的治疗效果。结果经3个月治疗后,TMS联合药物治疗组MMSE与ADL评分明显提高,其疗效明显优于单用药物治疗组(P<0.05)。结论经颅磁刺激(TMS)联合尼莫地平和多奈哌齐治疗血管性痴呆,对患者认知功能及日常生活能力均有明显改善,值得临床应用。Objective To analyze the clinical effect of transcranial magnetic stimulation （TMS） combined with nimodipine and donepezil on the treatment of vascular dementia. Methods Eighty cases of vascular dementia patients were chosen as the research objects, and they were randomly divided into TMS combined drug therapy group （42 cases） and drug therapy group （38 cases）. Patients in the two groups were both given conventional treatment, the drug therapy group was treated with nimodipine and donepezil on the basis of conventional treatment, while the TMS combined drug therapy group added TMS on the basis of drug therapy group. The therapeutic effect of the two groups were compared. Results TMS combined drug therapy group can significantly improve the MMSE and ADL scores 3 months after the treatment, which were significantly superior to that of drug therapy group （P〈0.05）. Conclusion For patients with vascular dementia, TMS combined with nimodipine and donepezil can significantly improve the cognitive function and daily living ability of the patients. So it is worthy of promoting.

关 键 词：血管性痴呆 经颅磁刺激治疗 尼莫地平 多奈哌齐 

分 类 号：R749.13[医药卫生—神经病学与精神病学]