生物检材中卡马西平的GC-MS检测  

Determination of Carbamazepine in the Biomaterial with GC-MS

作　　者：解润芳[1] 赵永和[1] 李玉雯 曾思火 王蕊[1] 

机构地区：[1]昆明医科大学法医学院,云南昆明650500 [2]云南省第三人民医院内分泌科,云南昆明650011

出　　处：《临床医药文献电子杂志》2016年第30期5929-5930,共2页Electronic Journal of Clinical Medical Literature

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项资金项目(项目编号:2014FB013;项目编号:2016FZ007)

摘　　要：目的 建立一种简便、快速、可靠的检测生物检材中卡马西平的方法。方法 丙酮：水（v/v8：2）对生物检材进行浸泡,然后在p H=10～11的条件下,用乙酸乙酯进行提取分离,GC-MS对样品进行检测。结果 该方法简单易操作,背景干扰小,分离效果好,分析速度快。结论 该方法可用于法医毒物分析生物检材中卡马西平的检验,结果满意。Objective To establish a simple, rapid and reliable method for the detection of C Masi Bing in biological samples. Methods Acetone：water （v/v 8：2） was soaked in biological samples, and then extracted and separated with ethyl acetate under the condition of pH=10 ～ 11, and the samples were detected by GC-MS. Results The method is simple and easy to operate, the background interference is small, the separation effect is good, and the analysis speed is fast. Conclusion This method can be applied to the analysis of C Masi Bing＇s test in the biological samples of forensic toxicological analysis, and the results are satisfactory.

关 键 词：法医毒物分析 GC-MS 生物检材 卡马西平 

分 类 号：R-33[医药卫生]