多西他赛联合顺铂治疗晚期头颈部肿瘤的效果观察  

Observation of clinical efficacy of Docetaxel plus Cisplatin in treatment of patients with advanced head and neck cancer

作　　者：李云[1] 罗乐[1] 何倩[1] 张琳[1] 韩亚骞[1] 刘峰[1] 刘林[1] 马宏志[1] 

机构地区：[1]湖南省肿瘤医院头颈放疗二科,湖南长沙410013

出　　处：《中国当代医药》2016年第30期62-64,共3页China Modern Medicine

摘　　要：目的观察多西他赛联合顺铂治疗晚期头颈部肿瘤的临床效果及毒副作用。方法将2013年12月-2015年12月我院收治的58例晚期头颈部肿瘤患者，依据不同的治疗方案分为观察组30例和对照组28例，观察组患者给予多西他赛联合顺铂治疗，对照组给予氟尿嘧啶联合顺铂治疗，治疗结束后1个月评价患者的临床效果及毒副作用。结果观察组有效率为66．7％，高于对照组的39．3％，差异有统计学意义（P〈0．05）。毒副作用主要表现为胃肠道反应、骨髓抑制，观察组胃肠道不良反应与骨髓抑制发生率明显低于对照组，差异有统计学意义（P〈0．05）。结论晚期头颈部肿瘤患者采用多西他赛联合顺铂化疗方案具有较为满意的临床疗效，且毒副作用轻微，值得临床推广应用。Objective To observe clinical efficacy and toxicity of Docetaxel plus Cisplatin in treatment of patients with advanced head and neck cancer.Methods 58 patients with advanced head and neck cancer in our hospital from De- cember 2013 to December 2015 were divided into observation group （n=30） and control group （n=28） according to dif- ferent treatment regimen.Patients in the observation group were given with Docetaxel plus Cisplatin treatment regimen, patients in the control group received Fluorouracil plus Cisplatin treatment regimen.The clinical efficacy and toxicity after a month were evaluated and compared between two groups after treatment for one month.Results The response rate in the observation group was 66.7%,higher than 39.3% in the control group,and the difference was statistically sig- nificant （P〈0.05）.The toxicities of two groups were mainly gastrointestinal reactions,bone marrow suppression,and inci- dence of gastrointestinal reactions and bone marrow suppression in observation group was obviously lower than that in the control group,and the difference was statistically significant （P〈0.05）.Conclusion Patients with advanced head and neck cancer treated by Docetaxel plus Cisplatin chemotherapy can get a more satisfactory clinical efficacy and mild toxicity and it should be introduced in clinical practice.

关 键 词：多西他赛 顺铂 晚期头颈部肿瘤 

分 类 号：R739.91[医药卫生—肿瘤]