1790例妇科门诊就诊者人乳头瘤病毒感染状况分析  

Prevalence of HPV among 1790 outpatients in gynecological clinic

作　　者：杨籽翾 李威[2] 徐萌[1] 绳波[1] 王熠[3] 计云霞[1] 王蕊[1] 李岚[1] YANG Zi-xuan LI Wei XU Meng SHENG Bo WANG Yi JI Yun-xia WANG Rui LI Lan(Capital Medical University, Beijing You an Hospital AIDS laboratory, Beijing 100069, China)

机构地区：[1]首都医科大学附属北京佑安医院艾滋病实验室,北京100069 [2]首都医科大学附属北京佑安医院肿瘤微创介入治疗中心,北京100069 [3]首都医科大学附属北京佑安医院检验科,北京100069

出　　处：《中国病毒病杂志》2016年第2期130-133,共4页Chinese Journal of Viral Diseases

基　　金：艾滋病研究北京市重点实验室项目(BZ 0089)

摘　　要：目的对1 790例妇科门诊就诊者的人乳头瘤病毒（HPV）感染状况进行分析。方法采用第二代杂交捕获法（HC-Ⅱ）对1 790份妇科门诊收集的宫颈组织样本进行HPV的初筛检测,应用SPSS 13.0软件进行数据分析,HPV阳性率的组间比较采用χ2检验。结果 1 790份标本中检测出708份HPV阳性标本,阳性率40.0%。在临床诊断为病毒性疣/尖锐湿疣患者中HPV阳性率为45.6%（377/826）,与健康查体组的阳性率间差异有统计学意义（P〈0.01）。在临床诊断为病毒性疣/尖锐湿疣组中HPV高载量的患者例数与该组患者总例数之比为18.2%（150/826）,与健康查体组的HPV高载量间差异有统计学意义（P=0.006）。病毒性疣/尖锐湿疣组中26～35岁年龄段的患者例数与该组患者总例数之比为20.0%（164/826）,与健康查体组的26～35岁年龄段之间差异有统计学意义（P〈0.01）。梅毒/宫颈炎/阴道炎组中26～35岁年龄段的患者例数与该组患者总例数之比为17.5%（104/593）,与健康查体组的26～35岁年龄段之间差异有统计学意义（P=0.012）。结论临床诊断为病毒性疣/尖锐湿疣患者中HPV阳性检出率较高,且HPV高载量患者所占比率较高,门诊就诊患者中26～35岁年龄段的女性人群是HPV的主要感染者。Objective To understand the current status of human papillomavirus （HPV） infection among 1 790 outpatients in gynecological clinic. Methods Cervical tissue specimens from 1 790 outpatients in gynecological clinic were collected and tested for HPV infection using the second generation hybrid capture assay （HC- Ⅱ ）. The experimental data were analyzed by SPSS 13.0 software, chi-square test was used for the analysis of the difference of HPV positive rates among groups. Results A total of 708 spechnens were HPV positive with the positive rate of 40.0%. The HPV positive rate was 45.6% （377/826） among clinically diagnosed patients with Condyloma Acuminatum and Viral Warts （CA/VW）, which was significantly higher than that of the healthy women （P〈0.01）. Also, the percentage of individuals with high HPV viral load among healthy check up women was much lower than that of those with clinically diagnosed CA/VW as well as with Syphilis/ Cervieitis/Vaginitis infections （P〈0.01）, especially in the age group of 26-35 years old （P〈0.01）. Conclusions The positive rate of HPV is much higher among women with clinically diagnosed CA/VW and percentage of patients with high HPV viral load is high as well. HPV infection is mainly found in outpatients aged 26- 3,5 years.

关 键 词：人乳头瘤病毒 尖锐湿疣 病毒性疣 

分 类 号：R737.33[医药卫生—肿瘤] R752.5[医药卫生—临床医学]