AEG-1、P16、KI-67蛋白在宫颈癌前病变中的表达与临床意义  

The expression of AEG- 1,P16,KI- 67 protein in precancerous cervical lesions and its clinical significance

作　　者：赵娟[1] 马唯[1] 吴林林[2] 陈隈陟[1] 刘凤阁[2] 

机构地区：[1]首都医科大学附属北京潞河医院妇产科,北京101100 [2]首都医科大学附属北京潞河医院病理科,北京101100

出　　处：《中国性科学》2016年第10期35-39,共5页Chinese Journal of Human Sexuality

基　　金：首都医科大学潞河教学医院院级资助课题项目

摘　　要：目的:探讨AEG-1、P16、KI-67蛋白在宫颈癌前病变中的表达与临床意义。方法:2008年2月至2015年9月选择在我院诊治的宫颈癌前病变患者98例作为癌前病变组,同期选择宫颈癌患者98例作为宫颈癌组和98例健康体检人作为对照组,取三组的宫颈样本都进行AEG-1、P16、KI-67蛋白表达的免疫组化分析,并调查了临床资料进行相关性分析。结果:AEG-1、P16、KI-67蛋白在宫颈癌组的阳性表达率分别为80.0%、93.9%和92.9%,而癌前病变组为57.1%、50.0%和57.1%,在对照组为3.1%、2.0%和4.1%,三组间对比差异有统计学意义(P<0.05)。AEG-1、P16、KI-67蛋白的阳性表达与宫颈癌前病变的年龄、疾病类型、HPV感染等病理参数对比差异有统计学意义(P<0.05)。直线相关性显示AEG-1、P16、KI-67蛋白表达都呈现两两正向相关性(P<0.05)。结论:AEG-1、P16、KI-67蛋白在宫颈癌前病变中都呈现高表达状况,且与临床病理特征存在相关性,三者可互相作用影响宫颈癌前病变的发展状况。Objectives： To investigate the expression of AEG- 1,P16,KI- 67 protein in the precancerous cervical lesions and its clinical significance. Methods： 98 patients of precancerous cervical lesions in our hospital from February 2008 to September 2015 were selected as the precancerous lesions group,98 patients of cervical cancer as the cervical cancer group,and 98 healthy people as the control group. The cervical samples in the three groups were taken for AEG- 1,P16,immunohistochemistry KI- 67 protein expression analysis,and the correlation of such clinical data was investigated. Results： The AEG- 1,P16,KI- 67 protein expression rates in the cervical cancer group were 80. 0 %,93. 9% and 92. 9% respectively,whereas those in the precancerous lesions group were57. 1%,50. 0% and 57. 1%,and in the control group were 3. 1%,2. 0% and 4. 1% respectively,with statistically significant difference among the three groups（ P〈 0. 05）. The AEG- 1,P16,KI- 67 protein expression rates in the precancerous lesions group were correlated to the cervical lesions age,type of disease and HPV infection（ P〈 0. 05）. According to linear correlations,AEG- 1,P16 and KI- 67 protein were positively correlated（ P〈 0. 05）.Conclusion： AEG- 1,P16 and KI- 67 proteins are highly expressed in precancerous cervical lesions,and are correlated to the clinicopathological characteristics. The interaction affects development of precancerous cervical lesion.

关 键 词：AEG-1 P16 KI-67 宫颈癌前病变 相关性 

分 类 号：R737.33[医药卫生—肿瘤]