肝细胞肝癌与活化的Cdc42结合蛋白激酶1的研究进展  

Activated Cdc42 kinase 1 and hepatocellular carcinoma

作　　者：曾青山[1] 谢斌辉[1] 谢元康[1] 王小农[1] 

机构地区：[1]赣南医学院第一附属医院肝胆外科,江西省赣州市341000

出　　处：《世界华人消化杂志》2016年第27期3853-3859,共7页World Chinese Journal of Digestology

摘　　要：原发性肝癌是指由肝细胞或肝内胆管上皮细胞发生的恶性肿瘤,简称肝癌.其发生率在各国和地区间差异很大,是我国常见的恶性肿瘤之一,死亡率高,在中国肿瘤相关性死亡率中排第2位.针对肝癌发病分子机制的研究是各大肝癌诊治中心的研究热点,其中对活化的Cdc42结合蛋白激酶1(activited Cdc42 kinase 1,ACK1)蛋白与肝癌相关性的研究在国内还是很少的.ACK1被发现在多种类型的肿瘤中过表达,并参与肿瘤的发生、发展,成为目前肿瘤信号传导通路研究的热点.本文拟就ACK1的结构特点、生物学功能及其与肝癌侵袭转移相关的研究进展进行简要综述.Primary liver cancer includes hepatocellular carcinoma（HCC） and cholangiocellular carcinoma.The incidence of HCC is different between countries and regions.As one of the common malignant tumors in China,HCC has high mortality and is the second most common cause of cancer-related death.Elucidating the molecular mechanism of HCC pathogenesis is important for the diagnosis and treatment of liver cancer in China.The expression of activated Cdc42 kinase 1（ACK1）has been found in a variety of cancers,and ACK1 participates in the occurrence and development of cancers.However,there are currently few studies about the relationship between ACK1 protein and HCC.This paper reviews the structure characteristics and biological function of ACK1 as well as its relationship with invasion and metastasis of HCC.

关 键 词：肝癌 活化的Cdc42结合蛋白激酶1 转移 肿瘤 蛋白激酶B 上皮间质转化 

分 类 号：R735.7[医药卫生—肿瘤]