子宫肌瘤组织中survivin的表达分析  

Expression analysis of Survivin in uterine leiomyoma

作　　者：徐国荣[1] 叶红[1] 

机构地区：[1]广东省江门市人民医院,广东江门529000

出　　处：《中国医药科学》2016年第16期81-83,90,共4页China Medicine And Pharmacy

摘　　要：【摘要】目的探讨Survivin在子宫肌瘤组织中的表达及其意义。方法用ELISA法检测2015年6～10月在我院因子宫肌瘤而行子宫切除的患者40例，对子宫肌瘤组织及其周边肌肉组织中Survivin蛋白含量进行监测对比。结果Survivin在子宫肌瘤瘤体组织中的含量是（310．78±25．93）ng／L，在瘤旁肌肉组织含量是（186．09±23．31）ng／L，二者差异有统计学意义（t=13．356，P〈0．01）；Survivin在单发子宫肌瘤瘤体组织含量是（312．54±28．78）ng／L，多发子宫肌瘤瘤体组织中含量（309．60±24．42）ng／L，二者之间无明显差异（f=1．0213，P〉0．05）。结论凋亡调节因子Survivin与子宫肌瘤的发生和发展密切相关。Objective To explore the expression and significance of Survivin in uterine leiomyoma. Methods ELISA method was used to detect the 40 cases of patients underwent hysterectomy due to uterine fibroids in our hospital from June 2015 to October 2015. Survivin protein content in uterine leiomyoma tissue and its peripheral muscle tissue were Monitored and compared. Results The content of Survivin in the uterine leiomyoma tissues was （310.78 ± 25.93） ng/L, the content of Survivin in muscle tissue was （186.09± 23.31） ng/L, and the difference was statistically significant （t=13,356, P 〈 0.01）. The content of Survivin in the tissue of solitary uterine leiomyoma was （312.54 ± 28.78） ng/L, the content of Survivin in multiple uterine fibroids （309.60 ± 24.42） ng/L, and there was no significant difference between the two groups （t=1.0213, P 〉 0.05）. Conclusion Apoptosis regulatory factor Survivin is closely related to the occurrence and development of uterine leiomyoma.

关 键 词：子宫肌瘤 SURVIVIN 发生机制 凋亡调节因子 

分 类 号：R737.33[医药卫生—肿瘤]