2011-2015年武汉市6617例女性患者HPV感染流行情况及亚型分析  

Epidemiological Investigation of HPV Infections and Subtype Analysis of 6,617 Female Cases in Wuhan Area from 2011 to 2015

作　　者：乔斌[1] 李艳[1] 汪明[1] 赖宇 

机构地区：[1]武汉大学人民医院检验科,湖北武汉430060 [2]江西医学高等专科学校,江西上铙334000

出　　处：《医学临床研究》2016年第10期1873-1875,1879,共4页Journal of Clinical Research

基　　金：国家重点临床专科建设项目[编号财社（2010）305号]

摘　　要：[目的]分析武汉地区门诊女性患者人乳头状瘤病毒（HPV）的流行情况及亚型分布情况，为HPV感染的预防和治疗提供依据。[方法]HPV感染和分型采用核酸分子快速导流杂交基因芯片技术进行检测，根据芯片上亚型分布位置判断阳性或阴性以及基因型。[结果]共计6617例患者进行HPV分型检测，其中1856例患者HPV检测阳性，阳性率28．05％；1856例患者共感染HPV亚型2543次，最常见的感染亚型为HPV16（30．28％）、HPV52（18．75％）、HPV58（15．03％）、HPV18（8．78％）、HPV33（8．51％）；其中，高危及高危合并低危亚型的感染率为91．11％，且随着年龄的增长而升高。HPV感染阳性女性主要集中在31～50岁年龄段，占66．16％，小于等于20岁的阳性率最高，达到35．05％；HPV感染以单一亚型感染为主，占73．06％，多重感染中以二重感染为主，常见的二重感染模式为HPV16＋HPV52、HPV16＋HPV58。[结论]武汉地区门诊女性患者HPV感染阳性率较高，主要集中在31～50岁年龄段，感染亚型以HPV16、HPV52、HPV58、HPV18、HPV33等高危型为主。[Objective]To investigate the epidemic and subtype distribution of human papilloma virus （HPV） of female outpatients in Wuhan in order to provide guidance for prevention and treatment of HPV infection. [Methods] HPV infection and typing were detected by DNA molecular rapid diversion hybridization gene chip technology, and the positive or negative and genotype were judged according to the location of the subtype distribution in the chip.[Results] HPV typing detection was performed in 6,617 patients, and 1,856 of them were positive for HPV, and the positive rate was 28.05%; 1,856 patients were infected with HPV subtype 2,543 times, The most common types of infection were HPV16 （30.28%）, HPV52 （18.75%）, HPV58 （15.03%）, HPV18 （8.78%） and HPV33 （8.51%） ; Among them, the infection rate of the high-risk combined with low-risk subtype was 91.11%, and increased with age. HPV infected women mainly concentrated in the age of 31-50 years old, accounting for 66.16%; the highest positive rate was among those younger or equivalent to 20 years old, reached 35.05 %; The single subtype of HPV infection took the majority , accounting for 73.06%. Among the multiple infections, the dual infection played a main role, and the common model for dual infection were HPV16 ＋ HPV52 and HPV16 ＋ HPV58.[Conclusion] The HPV infection rate of female outpatients in Wuhan is rather high, and the population is concentrated on 31-50 years old. The main infection genotypes include high risk subtypes like HPV16, HPV52, HPV58, HPV18 and HPV33.

关 键 词：乳头状瘤病毒科 寡核苷酸序列分析 蛋白质亚型 年龄分布 

分 类 号：R730.261.6[医药卫生—肿瘤]