精神分裂症患者利培酮治疗停药后的血脂水平变化  

Changes of Serum Lipids in Schizophrenic Patients after Withdrawal of Risperidone Treatment

作　　者：蔡丽莉 李立群 李洋 陈泳康 

机构地区：[1]广州市民政局精神病院,广东广州510430

出　　处：《医学临床研究》2016年第10期1935-1937,共3页Journal of Clinical Research

摘　　要：[目的]探讨精神分裂症患者利培酮治疗停药后的血脂变化。[方法]将本院收治的94例精神分裂症患者分为3组，首发未接受抗精神病药物治疗者33例（A组），持续接受抗精神病药物治疗者31例（B组），停止抗精神病药物利培酮治疗至少3个月以上者30例（C组）。另外选择32例健康志愿者作为正常对照（D组）。采集所有入组人员的一般临床资料和人口学资料，并测量其体质量，腰围和臀围，检测其空腹血清三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（apoA1）、载脂蛋白A2（apoA2）水平。[结果]A组血清HDL—C、apoA1水平显著低于D组，差异均具有统计学意义（均P〈0．05）；C组BMI显著高于A组，差异具有统计学意义（P〈0．05）；B组、C组血清HDL水平显著低于A组，差异具有统计学意义（P〈0．05）。[结论]精神分裂症患者利培酮治疗停药后短缺内不能逆转已经出现的血脂异常。[Objective]To investigate the changes of serum lipids in schizophrenic patients after withdrawal of risperidone treatment.[Methods] Ninety-three cases of schizophrenia in our hospital were divided into 3 groups, 33 patients （group A） were not treated with antipsychotic drugs, 31 patients （group B） were treated with antipsychotic drugs, and 30 patients ceased antipsychotic treatment the risperidone for at least 3 months or more （group C）. In addition, 32 healthy volunteers were selected as normal control group （group D）.[Results] The general clinical data and demographic data of all the patients were collected, and levels of body weight, waist and hip circumference, fasting serum three triglycerides （TG）, total cholesterol （TC）, high density lipoprotein （HDL-C）, low density lipoprotein cholesterol （LDL-C）, apolipoprotein A1 （apoA1） and apolipoprotein A2 （apoA2） were measured. BMI of the Group C was significantly higher than that of the Group A, the difference was statistically significant （ P 〈0.05）; The serum HDL level of the Group B and the Group C was significantly lower than that of A group, and the difference was statistically significant （ P 〈 0.05）.[Conclusion] The withdrawal of risperidone treatment in schizophrenic patients can not reverse the abnormal serum lipids in the short term.

关 键 词：精神分裂症/药物疗法 异恶唑类/治疗应用 哌啶类/治疗应用 脂类/血液 

分 类 号：R749.3[医药卫生—神经病学与精神病学]