术前新辅助化疗对进展期胃癌手术清除率及并发症的影响  

SOX Neoadjuvant Chemotherapy on the Surgical Removal and Postoperative Complications of Gastric Cancer Surgery in Advanced Stage Patients

作　　者：宋华勇[1] 张帆[1] 马磊[1] 

机构地区：[1]河南大学第一附属医院,河南开封475001

出　　处：《医学临床研究》2016年第10期1943-1945,共3页Journal of Clinical Research

摘　　要：[目的]探讨SOX方案新辅助化疗对Ⅱ～Ⅲ期进展期胃癌患者手术清除率及并发症的影响。[方法]本院收治的150例Ⅱ～Ⅲ期进展期胃癌患者随机分为观察组（54例）和对照组（51例）。对照组直接进行外科手术治疗，观察组进行SOX方案新辅助化疗后再进行胃癌根治手术。观察患者新辅助化疗效果、比较两组患者手术清除率和术后相关并发症的发生情况。[结果]观察组患者化疗前后肿瘤TNM分期下降显著（P〈0．05）。观察组患者手术时间（167．92±46．62）min和术中失血量（239．45±32．96）mL比对照组显著增加，且差异有显著性（P〈0．05）。观察组患者的R0切除率为90．74％（49／54），显著高于对照组68．62％（35／51）（P〈0．05）。两组患者并发症发生率相比较差异无显著性（P〉0．05）。[结论]进展期胃癌患者应用SOX方案新辅助化疗后可有效降低患者的肿瘤分期，提高手术清除率，并且不增加术后并发症的发生风险。[Objective]To explore the effects of the SOX neoadjuvant chemotherapy on the surgical clearance and complications in patients with advanced gastric cancer stage Ⅱ-Ⅲ and undergoing gastric cancer surgery. [Methods]One hundred and fifty cases of advanced gastric cancer were admitted into the study. The study subjects were randomly divided into the observation group （54 cases） and control group （51 cases）. The control group was only given the tradition gastric cancer surgery. The observation group underwent SOX neoadjuvant chemotherapy before undergoing traditional gastric cancer surgery. After the procedure, the postoperative clearance and complications were compared between the two groups. [Results]The observation group, through TNM staging, showed that tumor stage was significantly lower （ P〈0.05）. The observation group＇s surgical removal rate （90.74%） was significantly higher than that of the control group （ P〈0.05）. The operative time （167.92 min ± 46.62 min） and intraoperative blood loss （239.45 mL±32.96 mL） were significantly higher than in the control group （ P 〈0.05）. The postoperative complication rate was not significantly different between the two groups （P〉0.05）. [Conclusion]Application of SOX neoadjuvant chemotherapy in advanced gastric cancer patients undergoing gastric cancer surgery reduces the tumor stage, increases the surgical removal, and does not increase the risk of postoperative complications.

关 键 词：化学疗法 辅助 术前用药法 胃肿瘤/药物疗法 胃肿瘤/外科学 手术后并发症 

分 类 号：R735.2[医药卫生—肿瘤]