康复新液防治头颈部恶性肿瘤患者急性放射性口腔炎的疗效观察  

Effect of Kangfu Xinye on the Prevention and Treatment of Radiation-induced Oral Mucositis in Patients with Head and Neck Cancer

作　　者：阮方超[1] 王文敏[1] 林海升[1] 戴杰[1] 

机构地区：[1]浙江省台州医院,浙江台州318050

出　　处：《中国中医急症》2016年第11期2134-2136,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：浙江省中医药科学研究基金计划(2013ZA131);台州市路桥区科技计划(2013A23007)

摘　　要：目的 观察康复新液防治头颈部恶性肿瘤患者急性放射性口腔炎的效果。方法 68例患者随机分为康复新液组和对照组,各34例。自放射治疗开始至放疗结束,康复新液组予康复新液含服,每次10-15 m L,每天3-5次,对照组予维生素B1210 mg＋维生素B250 mg＋2%利多卡因5 m L＋地塞米松5 mg＋0.9%氯化钠注射液250 m L混合液口腔含漱,每次10-15 m L,每天3-5次。每周观察两组患者口腔黏膜反应并进行疼痛评分。结果 放疗第3周开始,康复新液组发生放射性口腔炎的程度均低于对照组（P〈0.05或P〈0.01）。放疗第3、5、6、7周康复新液组的疼痛评分（2.94±2.23）、（4.44±2.62）、（4.32±2.40）、（4.12±2.25）分,均分别低于对照组的（4.59±2.27）、（5.79±2.32）、（6.00±2.37）、（6.12±2.45）分（P〈0.05或P〈0.01）。结论 康复新液有助于降低头颈部恶性肿瘤患者放疗后放射性口腔炎的严重程度和口腔黏膜疼痛程度,有效提高生活质量。Objective： To investigate the effect of Kangfu Xinye on the prevention and treatment of radiation-in-duced oral mucositis in patients with head and neck cancer. Methods： 68 patients with head and neck cancer were randomly divided into two groups ： Kangfu Xinye group and the control groups. During the full course of ra- diotherapy,the experimental group were treated with Kangfu Xinye 10-15 mL each time, 3-5 times per day. The control groups were treated with mouth washes containing vitamin B12 10 mg,vitamin B2 50 mg,2% lidocaine 5 mL,dexamethasone 5 mg and 0,9% sodium chloride injection 250 mL gargle liquid mixture, 10-15 mL each time, 3 -5 times per day. Radiation-induced oral mucositis were assessed and the degree of pain grade was compared between the two groups weekly. Results： From the 3rd week, the degree of Radiation-induced oral mucositis were lower in the experimental group than that of the control group;the differences were statistically significant. In the 3^rd, 5^th, 6^th, 7^th week, the degree of pain grade was lower in the experimental group than those in the control group; the differences were statistically significant. The degree of pain grade in experimental group reached a peak at the 4^th week,and began to fall down slowly. Conclusion： Kangfu Xinye can reduce the severity of radiation stomatitis, alleviate the pain of patients, and improve the clinical symptoms of patients with head and neck cancer,worthy of wide clinical application.

关 键 词：头颈部恶性肿瘤 放射性口腔炎 放射治疗 康复新液 

分 类 号：R730.59[医药卫生—肿瘤]