非编码RNA在肝癌中的作用  

Role of Non-Coding RNA in Hepatocellular Carcinoma

作　　者：汪钰翔 傅枭男 赵明[1] 邬梦婷 丁先锋[1] 

机构地区：[1]浙江理工大学生命科学学院,杭州市310018

出　　处：《医学分子生物学杂志》2016年第5期302-306,共5页Journal of Medical Molecular Biology

摘　　要：近年来，国内外掀起RNA研究的热潮，焦点即为非编码RNA的生物作用机制。众多研究提示，非编码RNA （ non-coding RNA， ncRNA）在体内组成了复杂的分子网络，与蛋白质调控网络相对应，协同参与着肿瘤的发生发展、侵袭、转移和预后治疗。肝癌是最常见的恶性肿瘤疾病之一，在我国发病率极高，目前仍缺乏有效的治疗方式，严重威胁着人类健康。众多ncRNA在肝癌中表达失调，这些ncRNA作为肝癌基因治疗的潜在靶点，可推动肝癌基因靶向治疗的发展，研究意义重大。In recent years there has been a burst of researches on RNA, especially on the bio-logical mechanism of non-coding RNA （ ncRNA） . Numerous studies suggest that ncRNA, a com-ponent of complex molecular networks and protein regulatory networks, is involved in tumour growth, invasion, metastasis and prognosis. Liver cancer is one of the most common malignant dis-eases, with an extremely high incidence in China, and is still short of effective treatment. It poses a serious threat to human health. Many ncRNAs are found abnormally expressed in liver cancer. As ncRNA is a potential target for gene therapy, understanding ncRNA will promote the development of targeted gene therapy for liver cancer.

关 键 词：肝癌 非编码RNA 诊治 

分 类 号：R394.32[医药卫生—医学遗传学]