TWIST表达与恶性肿瘤转移关系的研究进展  

Relationship between TWIST and Metastasis of Malignant Tumor

作　　者：方雪妮 周天[1] 李泉旺[1] 胡凯文[1] FANG Xue-ni ZHOU Tian LI Quan-wang et al.(Dongfang Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100078)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《中国肿瘤》2016年第11期893-897,共5页China Cancer

基　　金：国家自然科学基金(81403250)

摘　　要：Twist是高度保守的碱性螺旋-环-螺旋转录因子,为新近发现的癌基因。Twist能够编码凋亡抑制蛋白,参与多种上皮来源肿瘤细胞的上皮间充质转化(EMT)过程,调控肿瘤血管、淋巴管的生成等过程,与肿瘤的侵袭、转移关系密切。目前已在多种肿瘤中发现Twist表达增高,开展Twist表达与肿瘤的侵袭转移关联性的研究对临床预防、治疗癌症转移意义重大。Twist is a highly conserved basic helix-loop-helix transcription factor,which is considered as an oncogene recently. Twist gene is involved in encoding inhibition of apoptosis protein and promoting epithelial-mesenchymal transition（EMT） in cancer,and may participate in tumor invasion and metastasis,angiogenesis and lymphangiogenesis. Study on the association of Twist with tumor invasion and metastasis would be of value in clinical prevention and treatment of cancer metastasis.

关 键 词：TWIST 肿瘤转移 EMT 血管形成 淋巴管形成 

分 类 号：R73[医药卫生—肿瘤]