肿瘤血管生成的分子机制与临床治疗研究进展  

Research Progress on Molecular Mechanism of Tumor Angiogenesis and its Relation to Clinical Treatment

作　　者：刘倩[1] 唐丽萍[1] 任晓霞[1] LIU Qian TANG Li-ping REN Xiao-xia(The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院,黑龙江哈尔滨150081

出　　处：《中国肿瘤》2016年第11期898-903,共6页China Cancer

摘　　要：在肿瘤中,肿瘤血管生成的分子成分包括细胞因子、生长因子、趋化因子及蛋白酶、信号转导通路等。大量研究表明,肿瘤血管生成的过程中会释放促血管生成的因子及酶类,通过肿瘤微环境促进肿瘤血管的进一步稳定与成熟,参与肿瘤的侵袭及转移,与多种肿瘤的发生发展密切相关。近年研究表明,在临床肿瘤治疗中,控制肿瘤血管生成的分子靶点是很有前景的治疗策略。Cytokines,growth factors,chemokines,protease and signal transduction pathway are the molecular components involving in the tumor angiogenesis. Studies have shown that proangiogenic factors and enzymes released during tumor angiogenesis promote the newly formed vessels further mature and stable with the tumor microenvironment,which participate in the invasion and metastasis of tumor. The molecules involving in tumor angiogenesis would be promising therapeutic targets for future cancer treatment strategies.

关 键 词：血管生成 肿瘤生长 转移 侵袭 靶向治疗 

分 类 号：R730.2[医药卫生—肿瘤]