三阴性乳腺癌整合素β1、p73的表达及临床意义  

Expressions of integrinβ1 and p73 in triple negative breast cancers and its clinical significance

作　　者：王瑞才[1] 郭方春 朱建友[1] 张海鹏[1] 徐少艳[1] 王爱云[1] 

机构地区：[1]山东省淄博市临淄区人民医院病理科,255400 [2]山东省淄博市临淄区人民医院超声科,255400

出　　处：《中国临床实用医学》2016年第5期26-29,共4页China Clinical Practical Medicine

摘　　要：目的研究整合素β1、抑癌基因p73在三阴性（ER-、PR-、HER2-）乳腺癌中的表达及意义，并探讨其与临床病理参数间的关系。方法应用免疫组织化学SP法检测整合素β1、抑癌基因p73在93例三阴性乳腺癌中的表达情况。选取同期诊断的58例非三阴性乳腺癌病例作为对照，分析两种蛋白表达的相关性及其与临床病理学特征之间的关系。结果三阴性乳腺癌中整合素β1的表达高于非三阴性乳腺癌（83．87％vs67．24％），差异有统计学意义（χ2=5．66，P=0．017）；p73的表达也高于非三阴性乳腺癌（65．59％vs46．55％），差异有统计学意义（χ2=5．33，P=0．021）。三阴性乳腺癌中整合素β1阳性表达与腋窝淋巴结转移（χ2=6．206，P=0．021）、临床分期（χ2=4．854，P=0．041）有关，而与患者年龄（χ2=0．121，P=0．783）、肿瘤大小（χ2=1．402，P=0．271）、组织学分级（χ2=1．042，P=0．376）无关；p73阳性表达与组织学分级（χ2=5．503，P=0．020）、腋窝淋巴结转移（χ2=4．626，P=0．047）、临床分期（χ2=5．828，P=0．024）有关，而与患者年龄（χ2=0．858，P=0．387）、肿瘤大小（χ2=0．875，P=0．388）无关。相关分析显示，在三阴性乳腺癌中整合素β1和p73的表达呈正相关（r=0．359，P=0．000）。结论p73作为抑癌基因有其组织特异性，整合素β1和p73可能共同参与三阴性乳腺癌的发生发展过程，可作为评估三阴性乳腺癌浸润和转移的重要生物学指标。Objective To study the expressions of integrin β1 and p73 in triple negative （ER-, PR-, HER2-） breast cancers and evaluate its clinical significance, exploring the relationship between clinieopathological parameters. Methods The immunohistochemistry SP methods was used to evaluate the expression of integrin β1 and p73 in 93 eases of triple negative breast cancer,58 cases of none triple negative breast cancer. The correlation of integrin β1 and p73 exprssion with elinieopathologic characteristics and between the two proteins were analyzed. Results The expression of integrin β1 in the triple negative breast cancers was significantly higher than those of none triple negative breast cancer（83.87% vs 67.24%）, with a significant difference（χ2=5.66,P=0.017）. The expression of p73 in the triple negative breast cancers was significantly higher than those of none triple negative breast cancer （65.59% vs 46.55%）, with a significant difference（χ2=5.33,P=0.021）. In triple negative breast cancers,integrin β1 expression was associated with axillary lymph node metastasis（χ2=6.206,P=0.021）and TNM stage（χ2=4.854,P=0.041）, but it was not correlated with patients age（χ2=0.121,P=0.783）, tumor size（χ2=1.402,P=0.271）and histologic grade（χ2=1.042,P=0.376）, p73 expression was associated with histologic grade（χ2=5.503,P=0.020）,axillary lymph node metastasis（χ2=4.626,P=0.047）and TNM stage（χ2=5.828,P=0. 024）, but it was not correlated with patients age（χ2=0.858,P=0.387）, tumor size（χ2=0.875,P=0.388）.Correlation analysis showed that integrin β1 expression was positively correlated with p73 expression in triple negative breast cancers（r=0.359,P=0.000）. Conclusions p73 has its tissue specificity, both integrin β 1 and p73 protein may participate in the development of triple negative breast cancers, and could serve as an important potential marker in the aspect of invasiveness and metastasis in triple negative breast cancers.

关 键 词：乳腺肿瘤 三阴性 免疫组织化学 整合素Β1 P73 

分 类 号：R737[医药卫生—肿瘤]