乙酰肝素酶和缺氧诱导因子-1α在宫颈癌淋巴管形成中的作用  

Role of heparanase and HIF-1α in lymphangiogenesis of cervical cancer

作　　者：曾超 姚运红 张淼[2] 尹金宝 李洪梅 唐加步 ZENG Chao YAO Yun-hongl ZHANG Miao YIN Jin-bao LI Hong-mei TANG Jia-bu(Department of Pathology, Guangdong Medical University, Dongguan 523808, China Department of Pathology, Maternal and Child Health Hospital of Xinhui District, Jiangmeng 529000, China)

机构地区：[1]广东医科大学病理教研室,广东东莞523808 [2]广东省江门市新会区妇幼保健院病理科,广东江门529000

出　　处：《广东医学院学报》2016年第2期137-139,共3页Journal of Guangdong Medical College

基　　金：国家自然科学基金资助项目(No.81302245)

摘　　要：目的探讨宫颈癌中乙酰肝素酶和缺氧诱导因子-表达及其与临床病理参数关系。方法 1α(HIF-1α)应用免疫组化法检测33例宫颈癌标本中乙酰肝素酶、表达,并分析二者与临床病理参数关系。结果 HIF-1α乙酰肝素酶阳性表达率为75.8%,与FIGO分期和淋巴结转移有关(P<0.05);HIF-1α阳性表达率为66.7%,与淋巴结转移有关(P<0.05)。乙酰肝素酶和HIF-1α阳性表达病例中淋巴管密度均显著高于阴性表达组(P<0.05)。乙酰肝素酶与HIF-1α表达呈显著正相关(r=0.758,P<0.05)。结论乙酰肝素酶表达与HIF-1α有关,二者参与宫颈癌淋巴管形成及淋巴结转移。Objective To explore the expression of heparanase and hypoxia inducible factor 1 alpha （HIF-1α） in cervical cancer and their relationship with clinicopathological parameters. Methods Expression of heparanase and HIF-1 ct in 33 cases of cervical cancer was detected by immtmohistochemistry, and relationship between their expression and clinicopathological parameters was analyzed. Results Heparanase expression rate was 75.8% and correlated with FIGO staging and nodal metastasis （P〈0.05）. HIF-la expression rate was 66.7% and correlated with nodal metastasis （P〈0.05）. The lymphatic vessel density was higher in the positive expression group of heparanase and HIF-1α than that in the negative expression group （P〈0.05）. Heparanase expression was positively correlated with HIF-1α （r=0.758, P〈0.05）. Conclusion Heparanase expression is related to HIF-1α, and both may be involve in lymphangiogenesis and nodal metastasis of cervical cancer.

关 键 词：宫颈癌 乙酰肝素酶 缺氧诱导因子-1Α 淋巴管形成 

分 类 号：R737[医药卫生—肿瘤]