105株沙门菌的血清型分布及药敏试验结果分析  

Serotype distribution and drug sensitivity test results: 105 strains of Salmonella

作　　者：何广概 黄潮新 曹传敏 郭日红[2] 全观伟 HE Guang-gai HUANG Chao-xin CAO Chuan-min GUO Ri-hong QUAN Guan-wei(Center for Disease Control and Prevention of Lianjiang, Lianjiang 524400, China Center for Disease Control and Prevention of Zhanjiang, Zhanjiang 524037, China Lianjiang People＇s Hospital, Lianjiang 524400, China)

机构地区：[1]广东省廉江市疾病预防控制中心,广东廉江524400 [2]广东省湛江市疾病预防控制中心,广东湛江524037 [3]广东省廉江市人民医院,广东廉江524400

出　　处：《广东医学院学报》2016年第2期192-194,共3页Journal of Guangdong Medical College

摘　　要：目的了解本地区沙门菌感染肠炎患者的血清型分布及其耐药情况,为流行病学研究及临床合理用药提供依据。方法用SS琼脂及伊红美兰琼脂培养基培养阳性的沙门氏菌,采用血清凝集法鉴定分型,同时采用K-B纸片法做药物敏感性试验。结果 105株沙门氏菌中鼠伤寒沙门菌39株(37.14%),肠炎沙门菌32株(30.48%),其他血清型散在分布。药敏结果显示,105株伤寒沙门菌对第三代头孢菌素(CTX)敏感率为100.0%,对四环素(TET)、氯霉素(CHL)、氨苄西林(AMP)、庆大霉素(GEN)和诺氟沙星(NFX)的敏感率均达90%以上;对环丙沙星(CIP)、萘啶酮酸(NAL)的敏感率分别为84.76%和82.86%,对CIP的耐药率为11.43%,对链霉素(STR)、复方新诺明(SXT)的敏感性较低,分别为65.71%和63.81%。结论本地区沙门菌感染引起的腹泻主要以鼠伤寒及肠炎沙门菌为主;应加强对沙门氏菌及其常用抗菌药物的药敏监测,指导临床合理用药。Objective To investigate serotype distribution and drug resistance of the patients with Salmonella enteritidis infections in the area in recent years, providing the evidence for epidemiological study and clinical rational drug use. Methods SS Agar and eosin methylene blue agar medium was used to culture positive Salmonella. Serum agglutination method Was used for typing while K - B paper method was used for drug sensitivity test. Results Of 105 Salmonella strains, there were 39 strains of Salmonella typhimurium （37.14%） and 32 strains of Salmonella enteritidis （30.48%）, and other serotypes are in diffused distribution. Drug sensitivity test results showed that the sensitive rate of 105 strains of Salmonella typhi to CTX was 100.0%; that to TET, CHL, Amp, GEN and NFX was all above 90%; that to CIP and NAL was 84.76% and 82.86% respectively, and the drug resistance rate to CiP was 11.43%; and the sensitivity to STR and SXT was relatively low, 65.71% and 63.81%, respec- tively. Conclusion Diarrhea caused by Salmonella infection in this area is mainly mouse typhus and Salmonella enteritidis. Therefore, drug sensitivity monitoring for Salmonella and its commonly used antibiotics shall be strengthened to guide clinical rational drug use.

关 键 词：沙门氏菌 血清型 药敏试验 

分 类 号：R516[医药卫生—内科学]