犬动脉瘤模型构建的瘤内血栓形成影响因素  

Influence factors of canine aneurysm membrane constructed tumor thrombus formation

作　　者：游文良 李欣[1] 王海波[1] 

机构地区：[1]延安大学咸阳医院神经外科,陕西咸阳712000

出　　处：《临床和实验医学杂志》2016年第21期2084-2087,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的 探讨犬动脉瘤模型构建的瘤内血栓形成影响因素。方法 20只成年比格犬运用静脉囊移植法建立犬颈动脉侧壁囊性动脉瘤,将其分为4组造模,每组5只。A组在颈动脉侧壁垂直缝合静脉囊将垂直型动脉瘤建立起来,术后不抗凝;B组在颈动脉侧壁倾斜缝合静脉囊头侧将倾斜型动脉瘤建立起来,术后不抗凝;C组将垂直型动脉瘤建立起来,术后抗凝;D组将倾斜性动脉瘤建立起来,术后抗凝。术后2~4周从股动脉穿刺对犬进行数字减影血管造影（DSA）,然后对造模结果、造影结果及影响因素进行统计分析。结果 有显著血栓形成于动脉瘤内8枚,A组、B组、C组、D组分别为5枚、2枚、1枚、0枚。倾斜型动脉瘤犬的瘤内血栓形成率17.5%（7/40）显著高于垂直型动脉瘤2.5%（1/40）（P〈0.05）,颈部血肿犬的瘤内血栓形成率15.0%（6/40）显著高于无颈部血肿犬5.0%（2/40）（P〈0.05）;倾斜型动脉瘤犬的瘤内血栓形成率显著低于垂直型动脉瘤犬（P〈0.05）。结论 犬动脉瘤模型构建的瘤内血栓形成影响因素包括动脉瘤形态、术后颈部血肿的发生情况,不包括术后抗凝。Objective To study the influence factors of canine aneurysm membrane constructed tumor thrombus formation. Methods 20 cases of adult beagle dogs were purchased from Shanghai Experimental Animal Center, Canine carotid cystic sidewall aneurysms was built by intra- venous bag transplantation. These dogs were divided into four groups modeling, 5 in each group. Group A were in the neck artery vein sidewall vertical suture aneurysm sac vertical type built without postoperative anticoagulant ; group B were in the side wall of the carotid artery balloon ce- phalic vein suture tilt aneurysms built without postoperative anticoagulation ; group C were vertical aneurysm established with postoperative anticoag- ulation; D group were inclined aneurysm with postoperative anticoagulation. Canine carotid sidewall aneurysm was built by intravenous bag, after 2 ~ 4 weeks dogs were performed DSA angiography from the femoral artery puncture, and then modeling results, angiographic results and influen- cing factors were statistically analyzed. Results There were 8 cases with significant thrombosis in the aneurysm, A group, B group, C group, D group of 5, 2, 1,0 respectively. The intratumoral thrombosis rate of the tilting aneurysm dogs 17.5% （7/40） was significantly higher than that of the vertical type aneurysm 2.5 % （1/40） （ P 〈 0.05 ）, the intratumoral thrombosis rate of the neck of the hematoma dog 15.0% （6/40） was significantly higher than that without neck hematoma dogs 5.0% （2/40） （ P 〈0.05 ）. The intratumoral thrombosis rate of the tilting aneurysm dogs was significantly lower than the vertical type of aneurysm dogs （ P 〈 0.05 ）. Conclusion Influence factors of Canine Model aneurysm tumor thrombosis include aneurysm morphology and occurrence of postoperative neck hematomas, but not include the postoperative anticoagulation.

关 键 词：犬 动脉瘤膜型 瘤内血栓形成 影响因素 

分 类 号：R-332[医药卫生] R543.5