根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果及存活质量、时间比较  

Comparison of the effects, survival quality and time between radical operation and palliative operation in treating patients with TNM Ⅲ stage pancreatic cancer

作　　者：奚诚[1,2] 江勇[1] 

机构地区：[1]苏州大学附属第三人民医院肝胆外科,江苏常州213000 [2]江苏大学附属武进医院肝胆外科,江苏常州213000

出　　处：《临床与病理杂志》2016年第10期1526-1530,共5页Journal of Clinical and Pathological Research

摘　　要：目的:比较根治手术与姑息手术治疗TNMⅢ期胰腺癌患者效果、存活质量及存活时间。方法:选择我院2011年1月至2014年12月收治的60例Ⅲ期胰腺癌患者进行回顾性分析,根据患者手术方式分为根治性手术组(A组,n=34)及姑息手术组(B组,n=26),比较两组术后并发症发生率、存活质量及术后1年、2年、3年生存率。结果:两组术后ClavienⅢ级、ClavienⅣ级及胰瘘发生率无统计学差异(P>0.05);A组Clav ienⅡ级发生率为41.2%,高于B组15.4%(P<0.05);A组各项生活质量评分均高于B组(P<0.05);术后1、2、3年生存率分别为44.2%、21.2%、16.1%,B组为15.4%、8.0%、0,无统计学差异(P>0.05)。结论:根治手术治疗TNMⅢ期胰腺癌患者可取得更佳效果,术后1、2、3年生存率均高于姑息手术组,生活质量更高,且术后并发症未明显增加,具有较大可行性。Objective：To compare the effects, survival quality and time between radical operation and palliative operation in treating patients with TNMⅢstage pancreatic cancer. Methods：Sixty patients withⅢstage pancreatic cancer who were treated in our hospital between January 2011 and December 2014 were divided into radical operation group （group A, n=34） and palliative operation group （group B, n=26）. hTe incidence of postoperative complications, survival quality and postoperative 1-, 2-and 3-year survival rates were compared between two groups. Results：There were no significant differences in ClavienⅢ, ClavienⅣand incidence of pancreatic ifstula between two groups atfer operation （P〉0.05）;the incidence rate of ClavienⅡin group A （41.2%） was signiifcantly higher than group B （15.4%） （P〈0.05）. Quality of life scores in group A were higher than group B （P〈0.05）. hTe 1-, 2-and 3-year survival rates in group A were 44.2%, 21.2%and 16.1%respectively, while in group B were 15.4%, 8.0% and 0, respectively （P〉0.05）. Conclusion： The effect of radical operation in the treatment of patients with TNM Ⅲ stage pancreatic cancer is better, and the postoperative 1-, 2- and 3-year survival rates are higher than palliative operation. The quality of life is higher and it will not increase postoperative complications.

关 键 词：胰腺癌 Ⅲ期 存活质量 根治手术 姑息手术 

分 类 号：R735.9[医药卫生—肿瘤]