枯草杆菌二联活菌联合利福昔明治疗小肠细菌过生长  

Live combined Bacillus subtilis and Enterococcus faecium granules combined with rifaximin for treatment of small intestinal bacterial overgrowth

作　　者：王喜莹 陈香宇[1] 

机构地区：[1]郑州大学第一附属医院消化内科,河南省郑州市450052

出　　处：《世界华人消化杂志》2016年第30期4200-4204,共5页World Chinese Journal of Digestology

摘　　要：目的探讨枯草杆菌二联活菌颗粒联合利福昔明治疗伴小肠细菌过生长(small intestinal bacterial overgrowth,SIBO)的腹泻型肠易激综合征患者的效果.方法选择2015-04/2016-04在郑州大学第一附属医院消化内科就诊的84例伴SIBO的腹泻型肠易激综合征患者作为研究对象,随机分为治疗组41例,对照组43例,治疗组给予利福昔明联合枯草杆菌二联活菌颗粒治疗,对照组给予利福昔明治疗,疗程为14 d,治疗结束后比较两组疗效.结果治疗组与对照组小肠细菌过度生长阳性者转阴率比较(85.37%vs 60.47%),差异有统计学意义(P<0.05);两组临床症状治疗有效率比较(92.69%vs 62.76%),差异有统计学意义(P<0.01).结论枯草杆菌二联活菌颗粒联合利福昔明治疗伴SIBO的腹泻型肠易激患者的效果明显.AIM To evaluate the efficacy of live combined Bacillus subtilis and Enterococcus faecium granules combined with rifaximin in the treatment of small intestinal bacterial overgrowth（SIBO）in patients with diarrhea-type irritable bowel syndrome（IBS）.METHODS From April 2015 to April 2016,84 IBS patients with SIBO treated at the First Affiliated Hospital of Zhengzhou University were included.The patients were randomly divided into either a treatment group（n = 41） or a control group（n = 43）.The treatment group received live combined Bacillus subtilis and Enterococcus faecium granules combined with rifaximin for14 d,while the control group received rifaximin alone.After treatment,the curative effect was compared between the two groups.RESULTS The rate of conversion from positive to negative SIBO was significantly higher in the treatment group than in the control group（85.37%vs60.47%,P 0.05）.There was also a statistically significant difference in the treatment efficiency between the treatment group and control group（92.69%vs 62.76%,P 0.01）.CONCLUSION The efficacy of rifaximin combined with live combined Bacillus subtilis and Enterococcus faecium granules is significant in IBS patients with SIBO.

关 键 词：腹泻型肠易激综合征 小肠细菌过生长 利福昔明 枯草杆菌二联活菌颗粒 

分 类 号：R574.4[医药卫生—消化系统]