趋化素样因子超家族成员3研究进展  

Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3

作　　者：胡风战 盛正祚 秦彩朋[1] 徐涛[1] HU Feng-zhan SHENG Zheng-zuo QIN Cai-peng XU Tao(Department of Urology, Peking University People＇ s Hospital, Beijing 100044, China)

机构地区：[1]北京大学人民医院泌尿外科,北京100044

出　　处：《中国医学科学院学报》2016年第3期360-363,共4页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81072099)~~

摘　　要：人趋化素样因子超家族成员3(CKLFSF3/CMTM3)是一种新发现的肿瘤抑制基因,在进化过程中高度保守,广泛表达于人类正常组织,尤其在睾丸、脾、白细胞中高度表达,但在大多数肿瘤细胞系和组织中表达下调或不表达,恢复其表达可抑制肿瘤细胞的增殖、黏附和迁移等生物学行为。CKLFSF3/CMTM3的抗肿瘤机制目前尚不明确,研究显示其在肿瘤发生发展过程中与机体免疫系统密切相关,并与性别相关。本文总结了CKLFSF/CMTM家族成员、肿瘤抑制基因CKLFSF3/CMTM3的结构功能特点及进展。CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member （CKLFSF/CMTM） is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal hu- man tissues and evolutionary conserved, especially in testis, spleen, and some cells of peripheral blood mono- nuclear cells. However, its expression is undetectable or down-regulated in most carcinoma cell lines and tis- sues. Restoration of CMTM3 may inhibit the proliferation, migration, and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear, CKLFSF3/CMTM3 is closely connected with im- mune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elabora- ted in this review as CMTM3 may be a new target in the gene therapies for tumors, especially genitourinary tumors, while further studies on CMTM3 and its anti-tumor mechanisms are warranted.

关 键 词：人趋化素样因子超家族成员3 肿瘤抑制基因 MARVEL 

分 类 号：R730.2[医药卫生—肿瘤]