喉癌前病变患者低温等离子射频消融术治疗前后嗓音功能的变化  

Voice acoustic study of plasma radiofrequency ablation for the treatment of laryngeal premalignant lesions

作　　者：臧艳姿[1] 万保罗[1] 贾晓东[1] 王广科[1] 

机构地区：[1]河南省人民医院(郑州大学人民医院)耳鼻咽喉科,郑州450003

出　　处：《临床耳鼻咽喉头颈外科杂志》2016年第22期1800-1803,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:研究低温等离子射频消融治疗喉癌前病变患者手术前后嗓音功能的变化及治疗效果。方法:选取50例喉癌前病变患者,患者术前及术后2周、1个月、3个月分别行电子喉镜检查观察声带恢复情况,并测试各项嗓音参数:基频(F0)、基频微扰(Jitter)、振幅微扰(Shimmer)、标准化噪声能量(NNE)。选取50例正常人作为对照组。结果:50例患者中,全部患者随访期满1年,术后一次性治愈47例(94%),患者术后嗓音功能明显改善,无呼吸困难、发声困难及声带粘连等并发症,嘶哑程度与手术范围及切除深度有关,术后2周时F0、Jitter、Shimmer、NNE值与对照组相比差异有统计学意义(P<0.01),术后1个月嗓音功能有所恢复,与对照组相比仍差异有统计学意义(P<0.05),术后3个月嗓音功能恢复稳定,声学参数与对照组对比差异无统计学意义(P>0.05)。结论:低温等离子射频术治疗喉癌前病变,患者嗓音功能恢复良好,具有微创、安全、并发症少等特点,值得临床推广。Objective：To study the voice function effect of low temperature plasma radiofrequency ablation in the treatment of patients with laryngeal premalignant lesions.Method：Fifty cases of laryngeal premalignant lesions were treated with low temperature plasma radiofrequency ablation.All of the patients were examined by electronic laryngoscopy and acoustic analysis（F0,Jitter,Shimmer,NNE,HNR）in 2weeks,1month,3months after surgery.Voice acoustic results were compared with a control group of 50 normal adults for the further analysis.Result：Fifty patients with laryngeal premalignant lesions were treated by low temperature plasma radiofrequency ablation.The result showed that 47patients（94%）were successfully decannulated without serious complications,such as dyspnea,aphonia and anterior glottic stenosis.Acoustic analysis showed that F0,Jitter,Shimmer and NNE were significantly different from normal 2weeks after surgery（P〈0.01）.Voice function recovered weakly 1month after operation（P〈0.05）.There were no significant differences in the vocal parameters between plasma radiofrequency ablation group and control group 3months after surgery（P〈0.05）.Conclusion：Radiofrequency coblation was a safe,minimally invasive and effective surgical method and can be widely used to treat laryngeal premalignant lesions.

关 键 词：低温等离子射频消融术 嗓音分析 喉癌前病变 

分 类 号：R739.6[医药卫生—肿瘤]