IL-1β基因C+3953T位点与自发性早产遗传易感性的病例对照研究  

Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study

作　　者：杨晓[1] 彭薇[1] 朱丽娜[1] 张小爱[2] 王艳[1] 

机构地区：[1]中国人民解放军陆军总医院附属八一儿童医院发育生物学实验室,北京100700 [2]军事医学科学院微生物和流行病学研究所病原微生物生物安全重点实验室,北京100071

出　　处：《中国当代儿科杂志》2016年第11期1123-1129,共7页Chinese Journal of Contemporary Pediatrics

基　　金：国家自然科学基金(81300527)

摘　　要：目的探讨白细胞介素-1β(IL-1β)基因C+3953T位点与自发性早产(SPTB)遗传易感性的关联性。方法病例组样本包括753例SPTB新生儿,对照组包括681例足月新生儿。采用最新的Sequenom Mass ARRAY?SNP检测技术对IL-1β基因C+3953T位点进行SNP分型。结果与携带IL-1β基因C+3953T位点的CC基因型的个体相比,携带至少一个T等位基因型(CT+TT基因型)的个体发生SPTB、合并胎膜早破的SPTB(PPROM)和轻度早产的风险显著升高。结论在中国人群中,IL-1β基因C+3953T位点与SPTB的患病风险的增加存在显著的遗传学关联。这一SNP位点的发现对于预防SPTB的发生,阐明SPTB的病因和发病机制具有重要意义。Objective To study the association between interleukin-1β（IL-1β） C＋3953T and genetic susceptibility to spontaneous preterm birth（SPTB）. Methods In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom Mass ARRAY？SNP detection technique was used for the typing of single nucleotide polymorphisms（SNP） of IL-1β C＋3953T. Results Compared with those carrying CC genotype of IL-1β C＋3953T, the neonates who carried at least one T allele（CT＋TT genotype） had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth. Conclusions In the Chinese population, IL-1β C＋3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.

关 键 词：白细胞介素-1Β 自发性早产 胎膜早破 单核苷酸多态性 新生儿 

分 类 号：R714.21[医药卫生—妇产科学]